Banks, H. ThomasKapraun, Dustin F.Thompson, W. ClaytonPeligero Cruz, Cristina, 1986-Argilaguet Marqués, Jordi, 1977-Meyerhans, Andreas2015-11-302015-11-302013Banks HT, Kapraun DF, Thompson WC, Peligero Cruz C, Argilaguet Marqués J, Meyerhans A. A novel statistical analysis and interpretation of flow cytometry data. J Biol Dyn. 2013;7:96-132. DOI: 10.1080/17513758.2013.8127531751-3758http://hdl.handle.net/10230/25267A recently developed class of models incorporating the cyton model of population generation structure into a conservation-based model of intracellular label dynamics is reviewed. Statistical aspects of the data collection process are quantified and incorporated into a parameter estimation scheme. This scheme is then applied to experimental data for PHA-stimulated CD4+T and CD8+T cells collected from two healthy donors. This novel mathematical and statistical framework is shown to form the basis for accurate, meaningful analysis of cellular behaviour for a population of cells labelled with the dye carboxyfluorescein succinimidyl ester and stimulated to divide.application/pdfeng© 2013 Taylor & Francis. This is an electronic version of an article published in Journal of biological dynamics. 2013. 7: 96-132. Journal of biological dynamics is available online at: www.tandfonline.com/doi/pdf/10.1080/17513758.2013.812753Cèl·lules TEstadística matemàticainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/17513758.2013.812753info:eu-repo/semantics/openAccess