García Prat, LauraMartínez Vicente, MartaMuñoz Cánoves, Pura, 1962-2016-06-152016-06-152016García-Prat L, Martínez-Vicente M, Muñoz-Cánoves P. Autophagy: a decisive process for stemness. Oncotarget. 2016; 7(11): 12286-12288. DOI 10.18632/oncotarget.77661949-2553http://hdl.handle.net/10230/26920Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate proteotoxicity and avoid senescence through basal autophagy. This protective "clean-up" system is lost during aging, resulting in stem cell regenerative decline. Thus, autophagy is required for muscle stem cell homeostasis maintenance.application/pdfengPublished originally by Impact Journals at http://dx.doi.org/10.18632/oncotarget.7766 under a Creative Commons Attribution 3.0 License.Músculs -- Envellimentinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.18632/oncotarget.7766AgingAutophagyMuscleSenescenceStem cellsinfo:eu-repo/semantics/openAccess