Desdentado, LorenaNavarrete, JaimeFolgado-Alufre, MaríaBlas, Ana deNavarro-Siurana, JéssicaPonce, Francisco J.Molinari, GuadalupeJimeno-Martínez, AndreaRupérez, Azahara I.Bueno-Lozano, GloriaCuenca Royo, Aida Ma, 1981-Corbella, EmiliAgüera, ZaidaBaños, Rosa M.Álvarez-Pitti, Julio2022-10-132022-10-132022Desdentado L, Navarrete J, Folgado-Alufre M, de Blas A, Navarro-Siurana J, Ponce F, Molinari G, Jimeno-Martínez A, Rupérez AI, Bueno-Lozano G, Cuenca-Royo A, Corbella E, Agüera Z, Baños RM, Álvarez-Pitti J. Are peripheral biomarkers determinants of eating styles in childhood and adolescence obesity? A cross-sectional study. Nutrients. 2022 Jan 12;14(2):305. DOI: 10.3390/nu140203052072-6643http://hdl.handle.net/10230/54359Disturbances in eating behaviors have been widely related to obesity. However, little is known about the role of obesity-related biomarkers in shaping habitual patterns of eating behaviors (i.e., eating styles) in childhood. The objective of the present study was to explore the relationships between several biomarkers crucially involved in obesity (ghrelin, insulin resistance, and leptin/adiponectin ratio) and eating styles in children and adolescents with obesity. Seventy participants aged between 8 and 16 (56.2% men) fulfilled the Spanish version of the Dutch Eating Behavior Questionnaire for Children to measure external, emotional, and restrained eating styles. In addition, concentrations of ghrelin, leptin, adiponectin, insulin, and glucose were obtained through a blood test. Hierarchical multiple regression analyses controlling for age and sex were computed for each eating style. Results indicated that individuals with higher ghrelin concentration levels showed lower scores in restrained eating (β = -0.61, p < 0.001). The total model explained 32% of the variance of the restrained pattern. No other relationships between obesity-related biomarkers and eating behaviors were found. This study highlights that one of the obesity-risk factors, namely lower plasma ghrelin levels, is substantially involved in a well-known maladaptive eating style, restraint eating, in childhood obesity.application/pdfeng© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/nu14020305AdiponectinAdolescentsChildrenEating behaviorEating stylesGhrelinInsulin resistanceLeptinLeptin/adiponectin ratioObesityinfo:eu-repo/semantics/openAccess