Davey, Christopher G.Pujol, JesúsHarrison, Ben J.2016-05-022016Davey CG, Pujol J, Harrison BJ. Mapping the self in the brain's default mode network. Neuroimage. 2016 May 15;132:390-7. doi: 10.1016/j.neuroimage.2016.02.0221053-8119http://hdl.handle.net/10230/26230The brain's default mode network (DMN) has become closely associated with self-referential mental activity, particularly in the resting-state. While the DMN is important for such processes, it has functions other than self-reference, and self-referential processes are supported by regions outside of the DMN. In our study of 88 participants, we examined self-referential and resting-state processes to clarify the extent to which DMN activity was common and distinct between the conditions. Within areas commonly activated by self-reference and rest we sought to identify those that showed additional functional specialization for self-referential processes: these being not only activated by self-reference and rest but also showing increased activity in self-reference versus rest. We examined the neural network properties of the identified 'core-self' DMN regions-in medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and inferior parietal lobule-using dynamic causal modeling. The optimal model identified was one in which self-related processes were driven via PCC activity and moderated by the regulatory influences of MPFC. We thus confirm the significance of these regions for self-related processes and extend our understanding of their functionally specialized roles.application/pdfeng© 2016 Elsevier.licensed under the Creative Commmons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://dx.doi.org/10.1016/j.neuroimage.2016.02.022Cervell -- FisiologiaCervell -- Localització de funcionsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.neuroimage.2016.02.022info:eu-repo/semantics/openAccess