Bárcena Menéndez, Diego, 1984-Senthivel, Vivek Raj, 1983-Isalan, Mark2015-11-092015-11-092015Barcena Menendez D, Senthivel VR, Isalan M. Sender–receiver systems and applying information theory for quantitative synthetic biology. Current opinion in biotechnology. 2015;31:101-7. DOI: 10.1016/j.copbio.2014.08.0050958-1669http://hdl.handle.net/10230/25027Sender–receiver (S–R) systems abound in biology, with communication systems sending information in various forms. Information theory provides a quantitative basis for analysing these processes and is being applied to study natural genetic, enzymatic and neural networks. Recent advances in synthetic biology are providing us with a wealth of artificial S–R systems, giving us quantitative control over networks with a finite number of well-characterised components. Combining the two approaches can help to predict how to maximise signalling robustness, and will allow us to make increasingly complex biological computers. Ultimately, pushing the boundaries of synthetic biology will require moving beyond engineering the flow of information and towards building more sophisticated circuits that interpret biological meaning.application/pdfeng© 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).Biologia sintèticaGenètica evolutivaTranscripció genètica -- Regulacióinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.copbio.2014.08.005info:eu-repo/semantics/openAccess