Sisteré-Oró, MartaDu, JuanWortmann, Diana D. J.Filippi, Marina D.Cañas-Ruano, EsperanzaArrieta Aldea, ItziarMarcos-Blanco, AgustínCastells, XavierGrau Cerrato, SantiagoGarcía-Giralt, NataliaPerez-Zsolt, DanielBoreika, RytisIzquierdo-Useros, NuriaGüerri Fernández, RobertoMeyerhans, Andreas2024-04-122024-04-122024Sisteré-Oró M, Du J, Wortmann DDJ, Filippi MD, Cañas-Ruano E, Arrieta-Aldea I, et al. Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination. J Med Virol. 2024 Jan;96(1):e29317. DOI: 10.1002/jmv.293170146-6615http://hdl.handle.net/10230/59743People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan-pox-specific T-cell responses in a cohort of HIV-1-infected individuals after receiving the nonreplicative, attenuated smallpox vaccine JYNNEOS from Bavarian Nordic. Intradermal (i.d.) and subcutaneous (s.c.) vaccination was safe without major side effects. Dose-sparing i.d. vaccination was superior to s.c. vaccination and promoted T-cell polyfunctionality, and the expression of the gut-homing marker α4β7 integrin on lymphocytes. HIV-1-infected individuals with CD4 T-cell counts ≤500/mm3 blood required at least a booster vaccination to exhibit efficient virus-specific T-cell responses. The magnitude of the Th1 response after this booster directly correlated with the CD4 T-cell count of the vaccinees. Further studies with a larger number of participants are warranted to confirm and expand our observations.application/pdfeng© 2023 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/jmv.29317HIV-1-infected individualsJYNNEOS vaccinationMonkeypox (mpox)Pan-pox-specific T-cell responsesinfo:eu-repo/semantics/openAccess