Zhu, YingSousa, André M. M.Gao, TianliuyunSkarica, MarioLi, MingfengSantpere Baró, Gabriel, 1981-Esteller Cucala, PaulaJuan, DavidFerrández Peral, Luis, 1991-Gulden, Forrest O.Yang, MoMiller, Daniel J.Marquès i Bonet, Tomàs, 1975-Kawasawa, Yuka ImamuraZhao, HongyuSestan, Nenad2019-12-172019-12-172018Zhu Y, Sousa AMM, Gao T, Skarica M, Li M, Santpere G et al. Spatiotemporal transcriptomic divergence across human and macaque brain development. Science. 2018;362(6420):eaat8077. DOI: 10.1126/science.aat80770036-8075http://hdl.handle.net/10230/43179Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. We generated tissue-level and single-cell transcriptomic data from up to 16 brain regions covering prenatal and postnatal rhesus macaque development. Integrative analysis with complementary human data revealed that global intraspecies (ontogenetic) and interspecies (phylogenetic) regional transcriptomic differences exhibit concerted cup-shaped patterns, with a late fetal-to-infancy (perinatal) convergence. Prenatal neocortical transcriptomic patterns revealed transient topographic gradients, whereas postnatal patterns largely reflected functional hierarchy. Genes exhibiting heterotopic and heterochronic divergence included those transiently enriched in the prenatal prefrontal cortex or linked to autism spectrum disorder and schizophrenia. Our findings shed light on transcriptomic programs underlying the evolution of human brain development and the pathogenesis of neuropsychiatric disorders.application/pdfengThis is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science. 2018; 362(6420). pii: eaat8077. DOI 10.1126/science.aat8077.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1126/science.aat8077info:eu-repo/semantics/openAccess