Agostini, Federico, 1985-Cirillo, DavideBolognesi, BenedettaTartaglia, Gian Gaetano2014-06-032014-06-032013Agostini F, Cirillo D, Bolognesi B, Tartaglia GG. X-inactivation: quantitative predictions of protein interactions in the Xist network. Nucleic Acids Res. 2013; 41(1): e31. DOI: 10.1093/nar/gks9680305-1048http://hdl.handle.net/10230/22553The transcriptional silencing of one of the female X-chromosomes is a finely regulated process that requires accumulation in cis of the long non-coding RNA X-inactive-specific transcript (Xist) followed by a series of epigenetic modifications. Little is known about the molecular machinery regulating initiation and maintenance of chromosomal silencing. Here, we introduce a new version of our algorithm catRAPID to investigate Xist associations with a number of proteins involved in epigenetic regulation, nuclear scaffolding, transcription and splicing processes. Our method correctly identifies binding regions and affinities of protein interactions, providing a powerful theoretical framework for the study of X-chromosome inactivation and other events mediated by ribonucleoprotein associations.application/pdfeng© 2013 Federico Agostini et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of a Creative Commons Attribution LicenseAlgoritmesCromosoma XRNAinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1093/nar/gks968info:eu-repo/semantics/openAccess