Spataro, Nino, 1984-Calafell i Majó, FrancescCervera-Carles, LauraCasals López, FerranPagonabarraga, JavierPascual Sedano, BertaCampolongo Perillo, AntòniaKulisevsky, Jaime J.Lleó, AlbertoNavarro i Cuartiellas, Arcadi, 1969-Clarimón Echevarría, JordiBosch Fusté, Elena2016-05-112016-05-112015Spataro N, Calafell F, Cervera-Carles L, Casals F, Pagonabarraga J, Pascual-Sedano B et al. Mendelian genes for Parkinson's disease contribute to the sporadic forms of the disease. Human molecular genetics. 2015; 24(7): 2023-2034. DOI 10.1093/hmg/ddu6160964-6906http://hdl.handle.net/10230/26269Parkinson's disease (PD) can be divided into familial (Mendelian) and sporadic forms. A number of causal genes have been discovered for the Mendelian form, which constitutes 10-20% of the total cases. Genome-wide association studies have successfully uncovered a number of susceptibility loci for sporadic cases but those only explain a small fraction (6-7%) of PD heritability. It has been observed that some genes that confer susceptibility to PD through common risk variants also contain rare causing mutations for the Mendelian forms of the disease. These results suggest a possible functional link between Mendelian and sporadic PD and led us to investigate the role that rare and low-frequency variants could have on the sporadic form. Through a targeting approach, we have resequenced at 49× coverage the exons and regulatory regions of 38 genes (including Mendelian and susceptibility PD genes) in 249 sporadic PD patients and 145 unrelated controls of European origin. Unlike susceptibility genes, Mendelian genes show a clear general enrichment of rare functional variants in PD cases, observed directly as well as with Tajima's D statistic and several collapsing methods. Our fapplication/pdfeng© Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Human molecular genetics following peer review. The definitive publisher-authenticated version Spataro N, Calafell F, Cervera-Carles L, Casals F, Pagonabarraga J, Pascual-Sedano B et al. Mendelian genes for Parkinson's disease contribute to the sporadic forms of the disease. Human molecular genetics. 2015; 24(7): 2023-2034. DOI 10.1093/hmg/ddu616 is available online at: http://hmg.oxfordjournals.org/content/24/7/2023.long.Parkinson, Malaltia de -- Aspectes genèticsPolimorfisme genèticinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1093/hmg/ddu616info:eu-repo/semantics/openAccess