Llauradó Cabot, GemmaCano, AlbertAlbert, LaraBallesta, SilviaMazarico, IsabelLuchtenberg, María-FlorenciaGonzález Sastre, MontserratMegia, AnaSimó, RafaelVendrell, JoanGonzález Clemente, José Miguel2020-03-272020-03-272019Llauradó G, Cano A, Albert L, Ballesta S, Mazarico I, Luchtenberg MF, et al. Arterial stiffness is highly correlated with the scores obtained from the steno type 1 risk engine in subjects with T1DM. PLoS One. 2019 Sep 4; 14(9):e0220206. DOI: 10.1371/journal.pone.02202061932-6203http://hdl.handle.net/10230/44058Objectives: Currently used risk scores for type 2 diabetes mellitus (T2DM) clearly underestimate cardiovascular risk in type 1 diabetes (T1DM). Hence, there is a need to develop novel and specific risk-estimation tools for this population. We aimed to assess the relationship between the Steno Type 1 Risk Engine (ST1RE) and arterial stiffness (AS), and to identify potential cut-off points of interest in clinical practice. Design and methods: A total of 179 patients with T1DM (50.8% men, mean age 41.2±13.1 years), without established cardiovascular disease, were evaluated for clinical and anthropometric data (including classical cardiovascular risk factors), and AS measured by aortic pulse-wave velocity (aPWV). The ST1RE was used to estimate 10-year cardiovascular risk and patients were classified into 3 groups: low- (<10%; n = 105), moderate- (10-20%; n = 53) and high-risk (≥20%; n = 21). Results: When compared with the low- and moderate-risk groups, patients in the high-risk group were older, had higher prevalence of hypertension, dyslipidemia and insulin-resistance, and had higher body-mass index and HbA1c. aPWV increased in parallel with estimated cardiovascular risk (6.4±1.0, 8.4±1.3 and 10.3±2.6m/s; p<0.001). As an evaluation of model performance, the C-statistic of aPWV was 0.914 (95% confidence interval [CI]:0.873-0.950) for predicting moderate/high-risk and 0.879 (95%CI:0.809-0.948) for high-risk, according to the ST1RE. The best cut-off points of aPWV were 7.3m/s (sensitivity:86%, specificity:83%) and 8.7m/s (sensitivity:76%, specificity:86%) for moderate/high- and high-risk, respectively. Conclusions: AS is highly correlated with the scores obtained from the ST1RE. We have identified two cut-off points of AS that can clearly discriminate moderate/high- and high-risk T1DM patients, which could be of great value in clinical practice.application/pdfeng© 2019 Llauradó et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Marcadors bioquímicsDiabetisinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1371/journal.pone.0220206info:eu-repo/semantics/openAccess