Talló Parra, Marc, 1992-Muscolino, ElenaDíez Antón, Juana, 1962-2023-03-022023-03-022022Talló-Parra M, Muscolino E, Díez J. The host tRNA epitranscriptome: A new player in RNA virus infections. Front Virol. 2022;2:1073619. DOI: 10.3389/fviro.2022.10736192673-818Xhttp://hdl.handle.net/10230/56009Viruses completely depend on the host translation machineries to express the viral proteins. Recent data reveal an unprecedented interaction of positive strand RNA ((+)RNA) viruses with the host tRNA epitranscriptome to favor viral protein expression via a specific reprogramming of codon optimality that ultimately favors decoding of the viral codons. We propose that this feature is shared by multiple RNA viruses and that the involved tRNA modifying enzymes represent promising novel targets for the development of broad-spectrum antivirals.application/pdfeng© 2022 Talló-Parra, Muscolino and Díez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.info:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fviro.2022.1073619tRNAtRNA modificationstRNA epitranscriptome(+)RNA virusesCHIKVKIAA1456VirusesCodon usageinfo:eu-repo/semantics/openAccess