Wang, PengKong, RuKong, XiaoluLiégeois, RaphaëlOrban, CsabaDeco, GustavoYeo, Thomas BT2019-01-212019-01-212019Wang P, Kong R, Kong X, Liégeois R, Orban C, Deco G, Van den Heuvel MP, Yeo BTT. Inversion of a large-scale circuit model reveals a cortical hierarchy in the dynamic resting human brain. Science Advances. 2019 Jan 09;5(1):eaat7854. DOI: 10.1126/sciadv.aat78542375-2548http://hdl.handle.net/10230/36350We considered a large-scale dynamical circuit model of human cerebral cortex with region-specific microscale properties. The model was inverted using a stochastic optimization approach, yielding markedly better fit to new, out-of-sample resting functional magnetic resonance imaging (fMRI) data. Without assuming the existence of a hierarchy, the estimated model parameters revealed a large-scale cortical gradient. At one end, sensorimotor regions had strong recurrent connections and excitatory subcortical inputs, consistent with localized processing of external stimuli. At the opposing end, default network regions had weak recurrent connections and excitatory subcortical inputs, consistent with their role in internal thought. Furthermore, recurrent connection strength and subcortical inputs provided complementary information for differentiating the levels of the hierarchy, with only the former showing strong associations with other macroscale and microscale proxies of cortical hierarchies (meta-analysis of cognitive functions, principal resting fMRI gradient, myelin, and laminarspecific neuronal density). Overall, this study provides microscale insights into a macroscale cortical hierarchy in the dynamic resting brain.application/pdfengCopyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1126/sciadv.aat7854info:eu-repo/semantics/openAccess