Rendón-Anaya, MarthaMontero-Vargas, Josaphat M.Saburido-Álvarez, SoledadVlasova, AnnaCapella Gutiérrez, Salvador Jesús, 1985-Ordaz-Ortiz, José JuanAguilar, O. MarioVianello-Brondani, Rosana P.Santalla, MartaDelaye, LuisGabaldón Estevan, Juan Antonio, 1973-Gepts, PaulWinkler, RobertGuigó Serra, RodericDelgado-Salinas, AlfonsoHerrera-Estrella, Alfredo2017-05-262017-05-262017Rendón-Anaya M, Montero-Vargas JM, Saburido-Álvarez S, Vlasova A, Capella Gutiérrez SJ, Ordaz-Ortiz JJ et al. Genomic history of the origin and domestication of common bean unveils its closest sister species. Genome Biology. 2017;18:60. DOI: 10.1186/s13059-017-1190-61474-760Xhttp://hdl.handle.net/10230/32167Background: Modern civilization depends on only a few plant species for its nourishment. These crops were derived via several thousands of years of human selection that transformed wild ancestors into high-yielding domesticated descendants. Among cultivated plants, common bean (Phaseolus vulgaris L.) is the most important grain legume. Yet, our understanding of the origins and concurrent shaping of the genome of this crop plant is limited. Results: We sequenced the genomes of 29 accessions representing 12 Phaseolus species. Single nucleotide polymorphism-based phylogenomic analyses, using both the nuclear and chloroplast genomes, allowed us to detect a speciation event, a finding further supported by metabolite profiling. In addition, we identified ~1200 protein coding genes (PCGs) and ~100 long non-coding RNAs with domestication-associated haplotypes. Finally, we describe asymmetric introgression events occurring among common bean subpopulations in Mesoamerica and across hemispheres. Conclusions: We uncover an unpredicted speciation event in the tropical Andes that gave rise to a sibling species, formerly considered the “wild ancestor” of P. vulgaris, which diverged before the split of the Mesoamerican and Andean P. vulgaris gene pools. Further, we identify haplotypes strongly associated with genes underlying the emergence of domestication traits. Our findings also reveal the capacity of a predominantly autogamous plant to outcross and fix loci from different populations, even from distant species, which led to the acquisition by domesticated beans of adaptive traits from wild relatives. The occurrence of such adaptive introgressions should be exploited to accelerate breeding programs in the near future.application/pdfengThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s13059-017-1190-6Common beanDomesticationGenomic introgressionAdaptive traitsSpeciationinfo:eu-repo/semantics/openAccess