Mateu de Antonio, Francisco JavierBerlana, DavidPons-Busom, MontserratBadia-Tahull, Maria B.Miana-Mena, María TeresaMartínez-Castro, BeatrizSunyer-Esquerrà, NeusSanmartin-Suñer, MónicaGonzález-Valdivieso, JuanLeiva-Badosa, ElisabetMartínez-Bernabé, EvaMurgadella-Sancho, AnnaMirerachs-Aranda, NuriaVila-Bundó, AnnaFernández-Morató, JordiVitales-Farrero, María Teresa2019-09-092019-09-092018Mateu-de Antonio J, Berlana D, Pons-Bussom M, Badia-Tahull MB, Miana-Mena MT, Martínez-Castro B, et al. Multicenter study of parenteral nutrition in non-critically ill elderly patients compared to younger patients -Study IAIOS-PN (Incidence and Assessment of Iatrogenesis in Older Subjects receiving Parenteral Nutrition). Nutr Hosp. 2018 Feb 27;35(2):252-258. DOI: 10.20960/nh.13930212-1611http://hdl.handle.net/10230/42254OBJECTIVE: this study assessed the incidence of hyperglycemia, hypertriglyceridemia, and liver function test (LFT) alterations among patients older and younger than 65 years receiving parenteral nutrition (PN). A secondary objective was to compare the incidence of any of these three events. MATERIAL AND METHODS: inclusion criteria were non-critically ill adult inpatients receiving PN for ≥ 7 days in 15 hospitals in Spain. Exclusion criteria were hyperglycemia, hypertriglyceridemia, LFT alterations, sepsis, shock, pancreatic/hepatobiliary surgery, renal failure, diabetes mellitus (DM) type 1, insulin-treated DM type 2, acute DM complications, or obesity prior to PN. Patients were classified into groups YOUNG (aged 35-64) and OLD (aged 65-95). RESULTS: this study recruited 200 patients. Group YOUNG included 63 (31.5%) patients and OLD, 137 (68.5%). Hyperglycemia appeared in 37 (18.5%) patients, eight (12.7%) in group YOUNG and 29 (21.2%) in group OLD (p = 0.174). Hypertriglyceridemia appeared in only one (0.7%) patient. LFT alterations appeared in 141 (70.5%) patients, 44 (69.8%) in group YOUNG and 97 (70.8%) in group OLD (p = 1.000). The model for hyperglycemia included DM type 2, previous surgical procedure, and use of hyperglycemia-inducing medications. The model for LFT alteration included previous surgical procedure, amount of lipids and amino acids, medications causing LFT alterations and a trend for age group. The model for any event included surgical procedure, DM type 2, and medications causing alterations. CONCLUSION: patients of ≥ 65 years receiving PN had similar incidences of hyperglycemia, hypertriglyceridemia, and LFT alterations as younger patients. Additionally, older patients had trends toward lower LFT alterations.application/pdfeng© Copyright 2018 SENPE y © Arán Ediciones S.L. Este es un artículo Open Access bajo la licencia CC BY-NC-SA (http://creativecommons.org/licenses/by-nc-sa/4.0/).Nutrició parenteralPersones grans -- AlimentacióJoves -- Alimentacióinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.20960/nh.1393info:eu-repo/semantics/openAccess