Climent Agustín, Marta CarmenMunarriz, MarinaBlazeby, Jane M.Dorcaratto, DimitriRamón Moros, José ManuelCarrera Santaliestra, M. JoséFontane Francia, LaiaGrande Posa, LuísPera Roman, Manuel Ramón2018-01-102017Climent M, Munarriz M, Blazeby JM, Dorcaratto D, Ramón JM, Carrera MJ. Et al. Weight loss and quality of life in patients surviving 2 years after gastric cancer resection. Eur J Surg Oncol. 2017 Jul;43(7):1337-1343. DOI: 10.1016/j.ejso.2017.01.2390748-7983http://hdl.handle.net/10230/33607BACKGROUND: Malnutrition is common in patients undergoing gastric cancer resection, leading to weight loss, although little is known about how this impacts on health-related quality of life (HRQL). This study aimed to explore the association between HRQL and weight loss in patients 2 years after curative gastric cancer resection. METHODS: Consecutive patients undergoing curative gastric cancer resection and surviving at least 2 years without disease recurrence were recruited. Patients completed the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and the specific module for gastric cancer (STO22) before and 2 years postoperatively and associations between HRQL scores and patients with and without ≥ 10% body weight loss (BWL) were examined. RESULTS: A total of 76 patients were included, of whom 51 (67%) had BWL ≥10%. At 2 years postoperatively, BWL ≥10% was associated with deterioration of all functional aspects of quality of life, with persistent pain (21.6%), diarrhoea (13.7%) and nausea/vomiting (13.7%). By contrast, none of the patients with BWL <10% experienced severe nausea/vomiting, pain or diarrhoea. CONCLUSIONS: Disabling symptoms occurred more frequently in patients with ≥10% BWL than in those with <10% BWL, with a relevant negative impact on HRQL. A cause-effect relationship between weight loss and postoperative outcome remains unsolved.application/pdfeng© Elsevier http://dx.doi.org/10.1016/j.ejso.2017.01.239Aparell digestiu -- CàncerEstómac -- CàncerQualitat de vidainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.ejso.2017.01.239Gastric cancerQuality of lifeSurgeryWeight lossinfo:eu-repo/semantics/openAccess