Duran, JoanSánchez Olavarría, PilarMola Caminal, MarinaGötzens, VíctorCarballo, JulioMartín Pelegrina, EvaPetit i Guinovart, MàriusAbdul-Jawad, OmarOtaegui, ImanolGarcía Blanco, BrunoGarcía-Dorado, DavidReig, JosepCordero, AlexAnta, Josep Maria2015-05-272015-05-272015Duran J, Olavarría PS, Mola M, Götzens V, Carballo J, Pelegrina EM. Genetic association study of coronary collateral circulation in patients with coronary artery disease using 22 single nucleotide polymorphisms corresponding to 10 genes involved in postischemic neovascularization. BMC Cardiovasc Disord. 2015 May 12;15(1):37. doi: 10.1186/s12872-015-0027-z.1471-2261http://hdl.handle.net/10230/23662BACKGROUND:/nCollateral growth in patients with coronary artery disease (CAD) is highly heterogeneous. Although multiple factors are thought to play a role in collateral development, the contribution of genetic factors to coronary collateral circulation (CCC) is largely unknown. The goal of this study was to assess whether functional single nucleotide polymorphisms (SNPs) in genes involved in vascular growth are associated with CCC. METHODS: 677 consecutive CAD patients were enrolled in the study and their CCC was assessed by the Rentrop method. 22 SNPs corresponding to 10 genes involved in postischemic neovascularization were genotyped and multivariate logistic regression models were adjusted using clinically relevant variables to estimate odds ratios and used to examine associations of allelic variants, genotypes and haplotypes with CCC. RESULTS: Statistical analysis showed that the HIF1A rs11549465 and rs2057482; VEGFA rs2010963, rs1570360, rs699947, rs3025039 and rs833061; KDR rs1870377, rs2305948 and rs2071559; CCL2 rs1024611, rs1024610, rs2857657 and rs2857654; NOS3 rs1799983; ICAM1 rs5498 and rs3093030; TGFB1 rs1800469; CD53 rs6679497; POSTN rs3829365 and rs1028728; and LGALS2 rs7291467 polymorphisms, as well as their haplotype combinations, were not associated with CCC (p < 0.05). CONCLUSIONS:/nWe could not validate in our cohort the association of the NOS3 rs1799983, HIF1A rs11549465, VEGFA rs2010963 and rs699947, and LGALS2 s7291467 variants with CCC reported by other authors. A validated SNP-based genome-wide association study is required to identify polymorphisms influencing CCC.application/pdfeng© 2015 Duran et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Malalties coronàriesArtèries coronàries -- Malaltiesinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s12872-015-0027-zinfo:eu-repo/semantics/openAccess