Fernandes, Henrique M.Van Hartevelt, Tim J.Boccard, Sandra G JOwen, Sarah L. F.Cabral, JoanaDeco, GustavoGreen, Alex L.FitzGerald, James J.Aziz, Tipu Z.Kringelbach, Morten L.2015-10-012015-10-012015Fernandes HM, Van Hartevelt TJ, Boccard SGJ, Owen SLF, Cabral J, Deco G et al. Novel fingerprinting method characterises the necessary and sufficient structural connectivity from deep brain stimulation electrodes for a successful outcome. New Journal of Physics. 2015;17. DOI: 10.1088/1367-2630/17/1/015001.1367-2630http://hdl.handle.net/10230/24786Deep brain stimulation (DBS) is a remarkably effective clinical tool, used primarily for movement/ndisorders. DBS relies on precise targeting of specific brain regions to rebalance the oscillatory behaviour/nof whole-brain neural networks. Traditionally, DBS targeting has been based upon animal/nmodels (such asMPTPfor Parkinson’s disease) but has also been the result of serendipity during/nhuman lesional neurosurgery. There are, however, no good animal models of psychiatric disorders/nsuch as depression and schizophrenia, and progress in this area has been slow. In this paper, we use/nadvanced tractography combined with whole-brain anatomical parcellation to provide a rational/nfoundation for identifying the connectivity ‘fingerprint’ of existing, successful DBS targets. This/nknowledge can then be used pre-surgically and even potentially for the discovery of novel targets. First,/nusing data from our recent case series of cingulate DBS for patients with treatment-resistant chronic/npain, we demonstrate how to identify the structural ‘fingerprints’ of existing successful and unsuccessful/nDBS targets in terms of their connectivity to other brain regions, as defined by the whole-brain/nanatomical parcellation. Second, we use a number of different strategies to identify the successful fingerprints/nof structural connectivity across four patients with successful outcomes compared with/ntwo patients with unsuccessful outcomes. This fingerprinting method can potentially be used presurgically/nto account for a patient’s individual connectivity and identify the best DBS target. Ultimately,/nour novel fingerprinting method could be combined with advanced whole-brain computational/nmodelling of the spontaneous dynamics arising from the structural changes in disease, to/nprovide new insights and potentially new targets for hitherto impenetrable neuropsychiatric/ndisorders.application/pdfengContent from this work may be used under the terms of the Creative Commons Attribution 3.0 licence.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1088/1367-2630/17/1/015001Deep brain stimulationFingerprintDiffusion imaginginfo:eu-repo/semantics/openAccess