Giralt-Steinhauer, EvaJiménez-Balado, JoanFernández-Pérez, IsabelRey Álvarez, LucíaRodríguez-Campello, AnaOis Santiago, Angel JavierCuadrado-Godia, ElisaJiménez Conde, JordiRoquer, Jaume2023-01-312023-01-312022Giralt-Steinhauer E, Jiménez-Balado J, Fernández-Pérez I, Rey Álvarez L, Rodríguez-Campello A, Ois Á, Cuadrado-Godia E, Jiménez-Conde J, Roquer J. Genetics and epigenetics of spontaneous intracerebral hemorrhage. Int J Mol Sci. 2022 Jun 9;23(12):6479. DOI: 10.3390/ijms231264791422-0067http://hdl.handle.net/10230/55491Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies.application/pdfeng© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/ijms23126479EpigeneticsGeneticsIntracerebral hemorrhageinfo:eu-repo/semantics/openAccess