Lázaro, IolandaRueda, FerranCediel, GermanOrtega, EmilioGarcía-García, CosmeSala Vila, AleixBayés-Genís, Antoni2021-11-052021-11-052020Lázaro I, Rueda F, Cediel G, Ortega E, García-García C, Sala-Vila A, et al. Circulating Omega-3 fatty acids and incident adverse events in patients with acute myocardial infarction. J Am Coll Cardiol. 2020 Nov 3; 76(18): 2089-97. DOI: 10.1016/j.jacc.2020.08.0730735-1097http://hdl.handle.net/10230/48920Background: Dietary omega-3 eicosapentaenoic acid (EPA) has multiple cardioprotective properties. The proportion of EPA in serum phosphatidylcholine (PC) mirrors dietary EPA intake during previous weeks. Circulating EPA in ST-segment elevation myocardial infarction (STEMI) relates to smaller infarct size and preserved long-term ventricular function. Objectives: The authors investigated whether serum-PC EPA (proxy for marine omega-3 consumption) levels at the time of STEMI were associated with a lower incidence of major adverse cardiovascular events (MACE), all-cause mortality, and readmission for cardiovascular (CV) causes at 3 years' follow-up. We also explored the association of alpha-linolenic acid (ALA, proxy for vegetable omega-3 intake) with all-cause mortality and MACE. Methods: The authors prospectively included 944 consecutive patients with STEMI (mean age 61 years, 209 women) undergoing primary percutaneous coronary intervention. We determined serum-PC fatty acids with gas chromatography. Results: During follow-up, 211 patients had MACE, 108 died, and 130 were readmitted for CV causes. A Cox proportional hazards model adjusted for known clinical predictors showed that serum-PC EPA at the time of STEMI was inversely associated with both incident MACE and CV readmission (hazard ratio [HR]: 0.76; 95% confidence interval [CI]: 0.62 to 0.94, and HR: 0.74; 95% CI: 0.58 to 0.95, respectively, for a 1-standard deviation [SD] increase). Serum-PC ALA was inversely related to all-cause mortality (HR: 0.65; 95% CI: 0.44 to 0.96, for a 1-SD increase). Conclusions: Elevated serum-PC EPA and ALA levels at the time of STEMI were associated with a lower risk of clinical adverse events. Consumption of foods rich in these fatty acids might improve the prognosis of STEMI.application/pdfengJournal of the American College of Cardiology. Lázaro el al. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an opec acces article under CC BY-NC-ND LICENSE (http://creativecommons.org/licenses/by-nc-nd/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jacc.2020.08.073MACEAlpha-linolenic acidEicosapentaenoic acidinfo:eu-repo/semantics/openAccess