Chamorro Servent, JuditAbascal, Juan Felipe Pérez JusteAguirre, JuanArridge, SimonCorreia, TeresaRipoll, JorgeDesco, ManuelVaquero, Juan J.2018-05-092018-05-092013Chamorro Servent J, Abascal JFPJ, Aguirre J, Arridge S, Correia T, Ripoll J, Desco M, Vaquero JJ. Use of Split Bregman denoising for iterative reconstruction in fluorescence diffuse optical tomography. Journal of Biomedical Optics. 2013;18(7):076016. DOI: 10.1117/1.JBO.18.7.0760161083-3668http://hdl.handle.net/10230/34603Fluorescence diffuse optical tomography (fDOT) is a noninvasive imaging technique that makes it possible to quantify the spatial distribution of fluorescent tracers in small animals. fDOT image reconstruction is commonly performed by means of iterative methods such as the algebraic reconstruction technique (ART). The useful results yielded by more advanced l1-regularized techniques for signal recovery and image reconstruction, together with the recent publication of Split Bregman (SB) procedure, led us to propose a new approach to the fDOT inverse problem, namely, ART-SB. This method alternates a cost-efficient reconstruction step (ART iteration) with a denoising filtering step based on minimization of total variation of the image using the SB method, which can be solved efficiently and quickly. We applied this method to simulated and experimental fDOT data and found that ART-SB provides substantial benefits over conventional ART.application/pdfeng© (2013) Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. Chamorro Servent J, Abascal JFPJ, Aguirre J, Arridge S, Correia T, Ripoll J, Desco M, Vaquero JJ. Use of Split Bregman denoising for iterative reconstruction in fluorescence diffuse optical tomography. Journal of Biomedical Optics. 2013;18(7):076016. http://dx.doi.org/10.1117/1.JBO.18.7.076016info:eu-repo/semantics/articlehttp://dx.doi.org/10.1117/1.JBO.18.7.076016FluorescenceDiffuseOpticalTomographyTotal variationSplit BregmanShrinkageAlgebraic reconstruction techniqueinfo:eu-repo/semantics/openAccess