López-Guimet, JúliaPeña-Pérez, LucíaBradley, Robert S.García-Canadilla, PatriciaDisney, CatherineGeng, HuaBodey, Andrew J.Withers, Philip J.Bijnens, BartSherratt, Michael J.Egea, Gustavo2019-03-252019-03-252018López-Guimet J, Peña-Pérez L, Bradley RS, García-Canadilla P, Disney C, Geng H, Bodey AJ, Withers PJ, Bijnens B, Sherratt MJ, Egea G. MicroCT imaging reveals differential 3D micro-scale remodelling of the murine aorta in ageing and Marfan syndrome. Theranostics. 2018;8(21):6038-52. DOI: 10.7150/thno.265981838-7640http://hdl.handle.net/10230/36954Aortic wall remodelling is a key feature of both ageing and genetic connective tissue diseases, which are associated with vasculopathies such as Marfan syndrome (MFS). Although the aorta is a 3D structure, little attention has been paid to volumetric assessment, primarily due to the limitations of conventional imaging techniques. Phase-contrast microCT is an emerging imaging technique, which is able to resolve the 3D micro-scale structure of large samples without the need for staining or sectioning.application/pdfeng© The authors. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.info:eu-repo/semantics/articlehttp://dx.doi.org/10.7150/thno.26598Marfan syndromeMicroCTAortaAgeingElastic lamellainfo:eu-repo/semantics/openAccess