de Prado-Bert, PaulaWarembourg, CharlineBorràs, EvaSabidó Aguadé, Eduard, 1981-Urquiza, José M.Maitre, LéaCasas Sanahuja, MaribelNieuwenhuijsen, Mark J.de Castro, MontserratBasagaña Flores, XavierVrijheid, MartineSunyer Deu, JordiBustamante Pineda, Mariona2022-05-252022-05-252022de Prado-Bert P, Warembourg C, Dedele A, Heude B, Borràs E, Sabidó E et al. Short- and medium-term air pollution exposure, plasmatic protein levels and blood pressure in children. Environ Res. 2022 Mar 12;211:113109. DOI:10.1016/j.envres.2022.1131090013-9351http://hdl.handle.net/10230/53260Exposure to air pollution influences children's health, however, the biological mechanisms underlying these effects are not completely elucidated. We investigated the association between short- and medium-term outdoor air pollution exposure with protein profiles and their link with blood pressure in 1170 HELIX children aged 6-11 years. Different air pollutants (NO2, PM10, PM2.5, and PM2.5abs) were estimated based on residential and school addresses at three different windows of exposure (1-day, 1-week, and 1-year before clinical and molecular assessment). Thirty-six proteins, including adipokines, cytokines, or apolipoproteins, were measured in children's plasma using Luminex. Systolic and diastolic blood pressure (SBP and DBP) were measured following a standardized protocol. We performed an association study for each air pollutant at each location and time window and each outcome, adjusting for potential confounders. After correcting for multiple-testing, hepatocyte growth factor (HGF) and interleukin 8 (IL8) levels were positively associated with 1-week home exposure to some of the pollutants (NO2, PM10, or PM2.5). NO2 1-week home exposure was also related to higher SBP. The mediation study suggested that HGF could explain 19% of the short-term effect of NO2 on blood pressure, but other study designs are needed to prove the causal directionality between HGF and blood pressure.application/pdfeng© 2022 Paula de Prado_Bert et al. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)Aire -- ContaminacióPressió sanguíniaInfantsProteïnesinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.envres.2022.113109info:eu-repo/semantics/openAccess