Merino, JanaPlanas, AdrianaMoner, Ana deGasol, AnaContreras, CarmenVidal-Barraquer, FrancescMarrugat de la Iglesia, JaumeClará Velasco, Alberto2025-12-032025-12-032008Merino J, Planas A, De Moner A, Gasol A, Contreras C, Marrugat J, Vidal-Barraquer F, Clarà A. The association of peripheral arterial occlusive disease with major coronary events in a mediterranean population with low coronary heart disease incidence. Eur J Vasc Endovasc Surg. 2008 Jul;36(1):71-6. DOI: 10.1016/j.ejvs.2008.01.0291078-5884http://hdl.handle.net/10230/72116Objectives: The association of peripheral arterial occlusive disease (PAD) association with major coronary events (MCE) has been well documented, nevertheless data are lacking for populations with a low incidence of coronary heart disease (CHD). We aimed to assess the association of PAD with MCE in a Mediterranean population. Design: Prospective survey of 699 55-74 year-old men representative of an urban district near Barcelona (Spain). Methods: Baseline cardiovascular risk factors, CHD and PAD (ankle/brachial index<0.9) were recorded. MCE were evaluated during the 5-year follow-up. Results: At recruitment 94 subjects (13.4%) had PAD. During follow-up (mean 69.3 months), 35 (5%) subjects suffered a MCE, of whom 12 had PAD, 9 previous symptomatic CHD and 1 subject both conditions. Higher CHD related mortality (8.6% vs 1.4%; p<0.001) and lower MCE-free survival (78.67% vs 93.26%; p<0.001) was observed for PAD subjects. On Cox regression analysis PAD (RR=3; p=0.003) and previous symptomatic CHD (RR=4.1; p<0.001) were associated independently with MCE during follow-up. Conclusions: Even in a population with a low incidence of CHD there is a strong relationship between PAD and future MCE. Screening for PAD may improve the selection of patients targeted for cardiovascular risk prevention.application/pdfeng© Elsevier http://dx.doi.org/10.1016/j.ejvs.2008.01.029info:eu-repo/semantics/article2025-12-03http://dx.doi.org/10.1016/j.ejvs.2008.01.029Cardiovascular diseasesRisk factorsCohort studiesPeripheral vascular diseasesCoronary diseaseinfo:eu-repo/semantics/openAccess