Sánchez Mut, Jose V.Heyn, HolgerVidal, EnriqueMoran, SebastianSayols, SergiDelgado Morales, RaulSchultz, Matthew D.Ansoleaga, BelénGarcía Esparcia, PaulaPons Espinal, Meritxell, 1986-Martínez de Lagrán Cabredo, MaríaDopazo, Jose M.Rábano, AlbertoÁvila, JesúsDierssen, MaraLott, Ira T.Ferrer, IsidreEcker, Joseph R.Esteller, Manel2016-06-032016-06-032016Sanchez-Mut JV, Heyn H, Vidal E, Moran S, Sayols S, Delgado-Morales R et al. Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns. Translational psychiatry. 2016; 6: e718. DOI 10.1038/tp.2015.2142158-3188http://hdl.handle.net/10230/26821Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared epigenetic aberrations, such as those affecting DNA methylation, might also exist. The studied samples were gray matter samples from the prefrontal cortex of control and neurodegenerative disease-associated cases. We performed the DNA methylation analyses of Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease and Alzheimer-like neurodegenerative profile associated with Down's syndrome samples. The DNA methylation landscapes obtained show that neurodegenerative diseases share similar aberrant CpG methylation shifts targeting a defined gene set. Our findings suggest that neurodegenerative disorders might have similar pathogenetic mechanisms that subsequently evolve into different clinical entities. The identified aberrant DNA methylation changes can be used as biomarkers of the disorders and as potential new targets for the development of new therapies.application/pdfeng© Nature Publishing Group. http://www.nature.com/tp/journal/v6/n1/full/tp2015214a.html/nThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.ADNSistema nerviós Degeneracióinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/tp.2015.214info:eu-repo/semantics/openAccess