Boronat i Llop, Susanna, 1965-Domènech, AlbaPaulo Mirasol, Esther, 1984-Calvo, Isabel A.García Santamarina, Sarela, 1978-García, PatríciaEncinar del Dedo, JavierBarcons-Simon, AnnaSerrano, EricaCarmona, MercèHidalgo Hernando, Elena2015-06-182015-06-182014Boronat S, Domènech A, Paulo E, Calvo IA, García-Santamarina S, García P et al. Thiol-based H2O2 signalling in microbial systems. Redox Biology. 2014;2:395-9. DOI: 10.1016/j.redox.2014.01.0152213-2317http://hdl.handle.net/10230/23855Cysteine residues, and in particular their thiolate groups, react not only with reactive oxygen species but also with electrophiles and with reactive nitrogen species. Thus, cysteine oxidation has often been linked to the toxic effects of some of these reactive molecules. However, thiol-based switches are common in protein sensors of antioxidant cascades, in both prokaryotic and eukaryotic organisms. We will describe here three redox sensors, the transcription factors OxyR, Yap1 and Pap1, which respond by disulfide bond formation to hydrogen peroxide stress, focusing specially on the differences among the three peroxide-sensing mechanisms.application/pdfeng© 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/)Escheríchia coliSaccharomyces cerevisiae -- MetabolismeSchizosaccharomyces pombe -- Metabolismeinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.redox.2014.01.015H2O2 sensorCys oxidationOxyRPap1Yap1S. pombeinfo:eu-repo/semantics/openAccess