Fort, JoaquimSolé Vicente, Ricard, 1962-2015-06-182015-06-182013Fort J, Solé Vicente R. Accelerated tumor invasion under non-isotropic cell dispersal in glioblastomas. New Journal of Physics. 2013;15:055001. DOI: 10.1088/1367-2630/15/5/0550011367-2630http://hdl.handle.net/10230/23850Glioblastomas are highly diffuse, malignant tumors that have so far evaded clinical treatment. The strongly invasive behavior of cells in these tumors makes them very resistant to treatment, and for this reason both experimental and theoretical efforts have been directed toward understanding the spatiotemporal pattern of tumor spreading. Although usual models assume a standard diffusion behavior, recent experiments with cell cultures indicate that cells tend to move in directions close to that of glioblastoma invasion, thus indicating that a biased random walk model may be much more appropriate. Here we show analytically that, for realistic parameter values, the speeds predicted by biased dispersal are consistent with experimentally measured data. We also find that models beyond reaction–diffusion–advection equations are necessary to capture this substantial effect of biased dispersal on glioblastoma spread.application/pdfengContent from this work may be used under the terms of the/nCreative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.Tumors -- TractamentCàncer -- Tractamentinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1088/1367-2630/15/5/055001info:eu-repo/semantics/openAccess