Dzierzak, ElaineBigas Salvans, Anna2019-03-262018Dzierzak E, Bigas A. Blood Development: Hematopoietic Stem Cell Dependence and Independence. Cell Stem Cell. 2018 May 3;22(5):639-651. DOI: 10.1016/j.stem.2018.04.0151875-9777http://hdl.handle.net/10230/36965Evidence of the diversity and multi-layered organization of the hematopoietic system is leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all long-lived hematopoietic cells derive from hematopoietic stem cells (HSCs). Here we review the current knowledge on HSC-dependent cell lineages and HSC-independent tissue-resident hematopoietic cells and how they arise during embryonic development. Classical embryological and genetic experiments, cell fate tracing data, single-cell imaging, and transcriptomics studies provide information on the molecular/cell trajectories that form the complete hematopoietic system. We also discuss the current developmentally informed efforts toward generating engraftable and multilineage blood cells.application/pdfeng© Elsevier http://dx.doi.org/10.1016/j.stem.2018.04.015Hematopoesiinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.stem.2018.04.015Embryonic hematopoiesisAGMEMPHematopotoietic stem cellHemogenic endotheliumPrimitive hematopoiesisinfo:eu-repo/semantics/openAccess