Gómez-Martín, IgnacioCollgros, HelenaFerguson, Peter M.Barreiro, AliciaGuitera, PascaleAndrades, EvelynPuig, SusanaPujol Vallverdú, Ramon MariaBarranco Sanz, Luis CarlosAlòs, LlúciaSegura Tigell, Sonia2021-05-042021-05-042021Gómez-Martín I, Collgros H, Ferguson PM, Barreiro A, Guitera P, Andrades-López E, et al. Diagnostic accuracy of pigmented labial macules by in vivo reflectance confocal microscopy and correlation among techniques. J Am Acad Dermatol. 2021 Nov;85(5):1151-1160. DOI: 10.1016/j.jaad.2020.02.0670190-9622http://hdl.handle.net/10230/47300Background: Pigmented labial macules (PLMs) are clinical, dermoscopic, and histopathologic challenges. Objective: To describe and evaluate the utility of reflectance confocal microscopy (RCM) in PLMs and to establish a correlation between dermoscopy, RCM, histopathology, and immunohistochemistry. Methods: Prospective study of PLMs from 4 tertiary referral dermatology centers. The study included 51 biopsy specimen-proven PLMs. Dermoscopic, RCM images, and histopathologic preparations were evaluated for malignant criteria. Diagnostic accuracy of RCM for melanoma diagnosis, RCM Lip Score previously reported, and κ values between techniques were calculated. Results: Included were 5 melanomas and 46 benign PLMs. Dermoscopically, melanomas exhibited more frequently ≥3 colors and ≥3 structures. With RCM, pagetoid spreading, epithelial disarray, continuous proliferation of atypical cells around papillae, nonhomogeneously distributed papillae, marked cellular atypia, and a higher number of dendritic cells per papillae were more frequent in melanomas. The RCM Lip Score was significantly higher in malignant lesions. Good κ values were observed in most of the evaluated features. A perfect sensitivity and specificity was obtained combining dermoscopy and RCM. Limitations: A low number of melanomas were obtained. Conclusions: RCM improves lip melanoma diagnosis, and the RCM Lip Score represents a useful tool for the evaluation of a PLM.application/pdfeng© Elsevier http://dx.doi.org/10.1016/j.jaad.2020.02.067info:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jaad.2020.02.067DermoscopyLabial maculeMelanomaMelanotic maculeReflectance confocal microscopyinfo:eu-repo/semantics/embargoedAccess