Borràs, EvaPastor, OlgaSabidó Aguadé, Eduard, 1981-2021-12-212021-12-212021Borràs E, Pastor O, Sabidó E. Use of linear ion traps in data-independent acquisition methods benefits low-input proteomics. Anal Chem. 2021 Aug 31;93(34):11649-11653. DOI: 10.1021/acs.analchem.1c018851520-6882http://hdl.handle.net/10230/51906The need for a better understanding of cellular heterogeneity has pushed mass spectrometry technologies to the analysis of single-cell and single-cell-type proteomes, although several challenges still limit their widespread implementation. Among the efforts toward single-cell and low-input analyses, there is the adoption of data-independent acquisition methods to increase analytical sensitivity. Here, we revisited the use of linear ion traps mass analyzers in data-independent acquisition methods and demonstrate their benefits to boost peptide and protein identifications in low-input proteomes.application/pdfeng© 2021 Eva Borràs, Olga Pastor i Eduard Sabidó. Published by American Chemical Society. https://creativecommons.org/licenses/by/4.0/GenèticaGenòmicaEspectrometria de massesinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1021/acs.analchem.1c01885info:eu-repo/semantics/openAccess