Solé Morata, Neus, 1988-García-Fernández, CarlaUrasin, VadimBekada, AsmahanFadhlaoui-Zid, KarimaZalloua, Pierre A.Comas, David, 1969-Calafell i Majó, Francesc2017-12-132017-12-132017Solé-Morata N, García-Fernández C, Urasin V, Bekada A, Fadhlaoui-Zid K, Zalloua P et al. Whole Y-chromosome sequences reveal an extremely recent origin of the most common North African paternal lineage E-M183 (M81). Sci Rep. 2017 Nov 21;7(1):15941. DOI: 10.1038/s41598-017-16271-y2045-2322http://hdl.handle.net/10230/33464E-M183 (E-M81) is the most frequent paternal lineage in North Africa and thus it must be considered to explore past historical and demographical processes. Here, by using whole Y chromosome sequences from 32 North African individuals, we have identified five new branches within E-M183. The validation of these variants in more than 200 North African samples, from which we also have information of 13 Y-STRs, has revealed a strong resemblance among E-M183 Y-STR haplotypes that pointed to a rapid expansion of this haplogroup. Moreover, for the first time, by using both SNP and STR data, we have provided updated estimates of the times-to-the-most-recent-common-ancestor (TMRCA) for E-M183, which evidenced an extremely recent origin of this haplogroup (2,000-3,000 ya). Our results also showed a lack of population structure within the E-M183 branch, which could be explained by the recent and rapid expansion of this haplogroup. In spite of a reduction in STR heterozygosity towards the West, which would point to an origin in the Near East, ancient DNA evidence together with our TMRCA estimates point to a local origin of E-M183 in NW Africa.application/pdfeng© Nature Publishing Group. http://dx.doi.org/10.1038/s41598-017-16271-y. https://creativecommons.org/licenses/by/4.0/Cromosoma YGenètica de poblacions humanes -- Àfrica del Nordinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41598-017-16271-yinfo:eu-repo/semantics/openAccess