Blanco Ares, Gonzalo, 1989-Puiggros Metje, Anna MariaRodríguez-Rivera, MaríaGimeno Vázquez, EvaAbella Monreal, EugeniaFerrer Del Alamo, AnaEspinet Solà, Blanca2017-02-082017-02-082016Blanco G, Puiggros A, Baliakas P, Athanasiadou A, García-Malo M, Collado R. et al. Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations. Oncotarget. 2016 Dec 6;7(49):80916-80924. doi: 10.18632/oncotarget.131061949-2553http://hdl.handle.net/10230/28084Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p-) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p- and 8q+ was 14.7% and 17.8% respectively. Both were associated with a significantly (P < 0.05) higher incidence of a complex karyotype (CK, ≥3 abnormalities) detected by chromosome banding analysis (CBA) compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate analysis for 10-year overall survival (OS), 8p- (P = 0.002), 8q+ (P = 0.012) and CK (P = 0.009) were associated with shorter OS. However, in multivariate analysis only CK (HR = 2.47, P = 0.027) maintained independent significance, being associated with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our results highlight the association of chromosome 8 abnormalities with CK amongst CLL patients with TP53abs, while also revealing that CK can further aggravate the prognosis of this aggressive subgroup.application/pdfengAll site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.Leucèmia aguda -- Aspectes genèticsLeucèmia limfocíticainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.18632/oncotarget.13106info:eu-repo/semantics/openAccess