Oliveras, TeresaLázaro, IolandaRueda, FerranCediel, GermanBhatt, Deepak L.Fitó Colomer, MontserratMadrid-Gambin, FranciscoPozo Mendoza, Óscar J., 1975-Harris, William S.García-García, CosmeSala Vila, AleixBayés-Genís, Antoni2022-10-182022-10-182022Oliveras T, Lázaro I, Rueda F, Cediel G, Bhatt DL, Fitó M, Madrid-Gambin F, Pozo OJ, Harris WS, García-García C, Sala-Vila A, Bayés-Genís A. Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation. Sci Rep. 2022 Mar 14;12(1):4377. DOI: 10.1038/s41598-022-08453-02045-2322http://hdl.handle.net/10230/54445Primary ventricular fibrillation (PVF) is a major driver of cardiac arrest in the acute phase of ST-segment elevation myocardial infarction (STEMI). Enrichment of cardiomyocyte plasma membranes with dietary polyunsaturated fatty acids (PUFA) reduces vulnerability to PVF experimentally, but clinical data are scarce. PUFA status in serum phospholipids is a valid surrogate biomarker of PUFA status in cardiomyocytes within a wide range of dietary PUFA. In this nested case-control study (n = 58 cases of STEMI-driven PVF, n = 116 control non-PVF STEMI patients matched for age, sex, smoking status, dyslipidemia, diabetes mellitus and hypertension) we determined fatty acids in serum phospholipids by gas-chromatography, and assessed differences between cases and controls, applying the Benjamini-Hochberg procedure on nominal P-values to control the false discovery rate (FDR). Significant differences between cases and controls were restricted to linoleic acid (LA), with PVF patients showing a lower level (nominal P = 0.002; FDR-corrected P = 0.027). In a conditional logistic regression model, each one standard deviation increase in the proportion of LA was related to a 42% lower prevalence of PVF (odds ratio = 0.58; 95% confidence interval, 0.37, 0.90; P = 0.02). The association lasted after the inclusion of confounders. Thus, regular consumption of LA-rich foods (nuts, oils from seeds) may protect against ischemia-driven malignant arrhythmias.application/pdfeng© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41598-022-08453-0CardiologyLipidomicsinfo:eu-repo/semantics/openAccess