Ritschka, Birgit,1985-Knauer-Meyer, TaniaSampaio Gonçalves, DanielMas, AlbaPlassat, Jean-LucDurik, MatejJacobs, HuguesPedone, Elisa, 1985-Di Vicino, UmbertoCosma, Maria Pia, 1970-Keyes, William M., 1973-2020-05-192020-05-192020Ritschka B, Knauer-Meyer T, Gonçalves DS, Mas A, Plassat JL, Durik M et al. The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice. Genes Dev. 2020 Apr 1; 34(7-8): 489-494. DOI: 10.1101/gad.332643.1190890-9369http://hdl.handle.net/10230/44600Young mammals possess a limited regenerative capacity in some tissues, which is lost upon maturation. We investigated whether cellular senescence might play a role in such loss during liver regeneration. We found that following partial hepatectomy, the senescence-associated genes p21, p16Ink4a, and p19Arf become dynamically expressed in different cell types when regenerative capacity decreases, but without a full senescent response. However, we show that treatment with a senescence-inhibiting drug improves regeneration, by disrupting aberrantly prolonged p21 expression. This work suggests that senescence may initially develop from heterogeneous cellular responses, and that senotherapeutic drugs might be useful in promoting organ regeneration.application/pdfengPublished originally by Cold Spring Harbor Laboratory Press at http://dx.doi.org/10.1101/gad.332643.119. Beginning six months from the full-issue publication date, articles are distributed under the Creative Commons Attribution-Non-Commercial 4.0 International License (CC-BY-NC), as described at http://creativecommons.org/licenses/by-nc/4.0/. This license permits non-commercial use, including reproduction, adaptation, and distribution of the article provided the original author and source are creditedFetge -- RegeneracióCèl·lules hepàtiquesEnvellimentSenilíticsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1101/gad.332643.119info:eu-repo/semantics/openAccess