Martínez-Huélamo, MiriamRodríguez-Morató, Jose, 1987-Boronat Rigol, Anna, 1990-Torre Fornell, Rafael de la2018-04-042018-04-042017Martínez-Huélamo M, Rodríguez-Morató J, Boronat A, de la Torre R. Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection. Antioxidants (Basel). 2017 Sep 26;6(4):73. DOI: 10.3390/antiox60400732076-3921http://hdl.handle.net/10230/34283Strong adherence to a Mediterranean diet is associated with improved cognitive function and a lower prevalence of mild cognitive impairment. Olive oil and red wine are rich sources of polyphenols which are responsible in part for the beneficial effects on cognitive functioning. Polyphenols induce endogenous antioxidant defense mechanisms by modulating transcription factors such as the nuclear factor (erythroid-derived 2)-like 2 (Nrf2). This review discusses the scientific data supporting the modulating effect of olive oil and red wine polyphenols on Nrf2 expression, and the potential health benefits associated with cognitive functioning.application/pdfengCopyright © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Oli d'oliva -- Aspectes nutricionalsVi -- Efectes fisiològicsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/antiox6040073Nrf2Cognitive functionHydroxytyrosolOlive oilPolyphenolsResveratrolWineinfo:eu-repo/semantics/openAccess