García Forero, CarlosSousa-Victor, PedroMuñoz Cánoves, Pura, 1962-2019-03-152019-03-152017García-Prat L, Sousa-Victor P, Muñoz-Cánoves P. Proteostatic and metabolic control of stemness. Cell Stem Cell. 2017 May 4;20(5):593-608. DOI: 10.1016/j.stem.2017.04.0111934-5909http://hdl.handle.net/10230/36844Adult stem cells, particularly those resident in tissues with little turnover, are largely quiescent and only activate in response to regenerative demands, while embryonic stem cells continuously replicate, suggesting profoundly different regulatory mechanisms within distinct stem cell types. In recent years, evidence linking metabolism, mitochondrial dynamics, and protein homeostasis (proteostasis) as fundamental regulators of stem cell function has emerged. Here, we discuss new insights into how these networks control potency, self-renewal, differentiation, and aging of highly proliferative embryonic stem cells and quiescent adult stem cells, with a focus on hematopoietic and muscle stem cells and implications for anti-aging research.application/pdfeng© Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.stem.2017.04.011 that appeared in the journal Cell stem cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: https://www.elsevier.com/about/our-business/policies/open-access-licenses/elsevier-user-licenseinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.stem.2017.04.011Stem cellsSatellite cellsHematopoietic stem cellsPluripotent stem cellsQuiescence autophagyProteostasisMetabolismMitochondriaAginginfo:eu-repo/semantics/openAccess