Falcón, CarlesGascon Merlos, Mireia, 1984-Molinuevo, José LuisOperto, GrégoryCirach, MartaGotsens, XavierFauria, KarineArenaza Urquijo, Eider M.Pujol Martí, Jesús, 1981-Sunyer Deu, JordiNieuwenhuijsen, Mark J.Gispert López, Juan DomingoCrous-Bou, MartaALFA Study2022-04-262022-04-262021Falcón C, Gascon M, Molinuevo JL, Operto G, Cirach M, Gotsens X, Fauria K, Arenaza-Urquijo EM, Pujol J, Sunyer J, Nieuwenhuijsen MJ, Gispert JD, Crous-Bou M. Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population. Alzheimers Dement (Amst). 2021 Jul 5;13(1):e12205. DOI: 10.1002/dad2.122052352-8729http://hdl.handle.net/10230/52892Introduction: Urban environmental exposures might contribute to the incidence of Alzheimer's disease (AD). Our aim was to identify structural brain imaging correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk of AD. Methods: Two hundred twelve participants with brain scans and residing in Barcelona, Spain, were included. Land use regression models were used to estimate residential exposure to air pollutants. The daily average noise level was obtained from noise maps. Residential green exposure indicators were also generated. A cerebral 3D-T1 was acquired to obtain information on brain morphology. Voxel-based morphometry statistical analyses were conducted to determine the areas of the brain in which regional gray matter (GM) and white matter (WM) volumes were associated with environmental exposures. Results: Exposure to nitrogen dioxide was associated with lower GM volume in the precuneus and greater WM volume in the splenium of the corpus callosum and inferior longitudinal fasciculus. In contrast, exposure to fine particulate matter was associated with greater GM in cerebellum and WM in the splenium of corpus callosum, the superior longitudinal fasciculus, and cingulum cingulate gyrus. Noise was positively associated with WM volume in the body of the corpus callosum. Exposure to greenness was associated with greater GM volume in the middle frontal, precentral, and the temporal pole. Discussion: In cognitively unimpaired adults with increased risk of AD, exposure to air pollution, noise, and green areas are associated with GM and WM volumes of specific brain areas known to be affected in AD, thus potentially conferring a higher vulnerability to the disease.application/pdfeng© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/dad2.12205Alzheimer's diseaseAir pollutionBrain imagingGreennessNoisePreventionRisk factorsinfo:eu-repo/semantics/openAccess