Repositori digital de la UPF: Envíos recientes

  • Using in vivo oxidation status of one- and two-component redox relays to determine H2O2 levels linked to signaling and toxicity
    Domènech, Alba; Ayté del Olmo, José; Antunes, Fernando; Hidalgo Hernando, Elena (BioMed Central, 2018)
    BACKGROUND: Hydrogen peroxide (H2O2) is generated as a by-product of metabolic reactions during oxygen use by aerobic organisms, and can be toxic or participate in signaling processes. Cells, therefore, need to be able to ...
  • The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity
    Doñate-Macián, Pau; Jungfleisch, Jennifer, 1986-; Pérez Vilaró, Gemma, 1985-; Rubio Moscardó, Fanny; Perálvarez Marín, Alex; Díez Antón, Juana, 1962-; Valverde, M. A. (Miguel Ángel), 1963- (Nature Publishing Group, 2018)
    Ion channels are well placed to transduce environmental cues into signals used by cells to generate a wide range of responses, but little is known about their role in the regulation of RNA metabolism. Here we show that the ...
  • Statin-associated muscle symptoms: beware of the nocebo effect
    Pedro-Botet, Juan Carlos; Rubiés, Joan-Pau (Elsevier, 2017)
  • Proton Pump Inhibitor Usage and the Risk of Mortality in Hemodialysis Patients
    de Francisco, Angel Luis M.; Varas, Javier; Ramos, Rosa; Merello, Ignacio; Canaud, Bernard; Stuard, Stefano; Pascual Santos, Julio; Aljama, Pedro; Optimizing Results in Dialysis (ORD) group (Elsevier, 2017)
    INTRODUCTION: Long-term inappropriate proton pump inhibitors use (PPIs) is a matter of concern because of the risks associated with their long-term use in older patients with chronic conditions. The risk of PPI treatment ...
  • CT scans in children and young adults and cancer risk: the Spanish EPI-CT cohort
    Bosch de Basea i Gómez, Magda, 1982- (Universitat Pompeu Fabra, 2016-11-28)
    The present thesis introduces the EPI-CT cohort study; a European collaborative effort aimed at quantifying the health risks of computed tomography (CT scan) radiation exposure during childhood and assesses the main ...
  • La sepat dels dos ceptres-uas a la llum de les processons geogràfiques: recerques en Geografia sagrada i "teologia" local a l'antic Egipte
    Torras Benezet, Núria, (Universitat Pompeu Fabra, 2016-01-29)
    Aquest treball analitza la conceptualització i representació de la sepat dels dos ceptres-uas en el context de la Geografia sagrada d'Egipte des d'una perspectiva diacrònica a partir de la documentació papirològica i ...
  • Effectiveness of an intervention of urban training in patients with chronic obstructive pulmonary disease (COPD): a randomised controlled trial
    Arbillaga Etxarri, Ane, 1986- (Universitat Pompeu Fabra, 2016-12-20)
    High levels of physical activity have been related to better prognosis in patients with chronic obstructive pulmonary disease (COPD). However, so far no interventions have proven effective to modify physical activity in ...
  • Computational tool for visualization, analysis and comparison of epigenomes
    Reina García, Óscar, 1976- (Universitat Pompeu Fabra, 2018-04-10)
    We developed a computational framework implemented as an R package for generation, visualization and functional and differential analysis of epigenome maps. Methods are provided for integrating and comparing data from ...
  • Improving the recovery of genomic information from complex samples
    Hernández Rodríguez, Jéssica, 1983- (Universitat Pompeu Fabra, 2018-06-08)
    The innovation of genomics has progressed at pace with the development of high-throughput DNA sequencing technologies. Prior to the outbreak of next-generation sequencing, retrieving genetic information was limited to a ...
  • The Role of occupational exposures in Chronic Obstructive Pulmonary Disease
    Lytras, Theodoros, 1987- (Universitat Pompeu Fabra, 2018-05-22)
    Introduction: Occupational exposures are considered to be one of the newer and important risk factors for Chronic Obstructive Pulmonary Disease (COPD) besides tobacco smoking. However, the evidence mostly comes from smaller ...
  • Control of S-phase progression in response to stress
    Canal de Torres, Berta, 1988- (Universitat Pompeu Fabra, 2018-02-16)
    In response to multiple internal and external stresses, yeast cells activate a common transcriptional response known as the Environmental Stress Response (ESR), which can be problematic in S phase, when DNA is being ...
  • Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors
    Martin-Trujillo, Alex; Vidal Ocabo, Enrique; Monteagudo-Sánchez, Ana; Sanchez-Delgado, Marta; Moran, Sebastian; Hernández Mora, José Ramón; Heyn, Holger; Guitart, Miriam; Esteller, Manel; Monk, David (Nature Publishing Group, 2017)
    It has been postulated that imprinting aberrations are common in tumors. To understand the role of imprinting in cancer, we have characterized copy-number and methylation in over 280 cancer cell lines and confirm our ...
  • A reporter system coupled with high-throughput sequencing unveils key bacterial transcription and translation determinants
    Yus, Eva; Yang, Jae Seong; Sogues, Adrià; Serrano Pubull, Luis, 1982- (Nature Publishing Group, 2017)
    Quantitative analysis of the sequence determinants of transcription and translation regulation is relevant for systems and synthetic biology. To identify these determinants, researchers have developed different methods of ...
  • Molecular basis of differential 3' splice site sensitivity to anti-tumor drugs targeting U2 snRNP
    Vigevani, Luisa, 1985-; Gohr, André; Webb, Thomas R.; Irimia, Manuel; Valcárcel, J. (Juan) (Nature Publishing Group, 2017)
    Several splicing-modulating compounds, including Sudemycins and Spliceostatin A, display anti-tumor properties. Combining transcriptome, bioinformatic and mutagenesis analyses, we delineate sequence determinants of the ...
  • The Combination of Beta Blockers and Renin-Angiotensin System Blockers Improves Survival in Incident Hemodialysis Patients: A Propensity-Matched Study
    Luño, José; Varas, Javier; Ramos, Rosa; Merello, Ignacio; Aljama, P.; MartinMalo, Alejandro; Pascual Santos, Julio; Praga, Manuel; ORD Group; INTRODUCTION: Although several studies suggest that the prognosis of hypertensive dialysis patients can be improved by using antihypertensive drug therapy, it is unknown whether the prescription of a particular class or combination of antihypertensive drugs is beneficial during hemodialysis. METHODS: We performed a propensity score matching study to compare the effectiveness of various classes of antihypertensive drugs on cardiovascular (CV) mortality in 2518 incident hemodialysis patients in Spain. The patients had initially received antihypertensive therapy with a renin-angiotensin system (RAS) blocker (728 patients), a ß-blocker (679 patients), antihypertensive drugs other than a RAS blocker or a ß-blocker (787 patients), or the combination of a ß-blocker and a RAS inhibitor (324 patients). These patients were followed for a maximum of 5 years (median: 2.21 yr; range: 1.04-3.34 yr). RESULTS: After adjustment for baseline CV risk covariates, no significant differences were observed in the risk of CV mortality between patients taking a RAS blocker and patients treated with ß-blocker-based antihypertensive therapy. The combination of a RAS blocker with a ß-blocker was associated with better CV survival than either agent alone (RAS blocker: hazard ratio [HR]: 1.68; 95% confidence interval [CI] 1.05-2.69; ß-blocker: HR: 1.59; 95% CI: 1.01-2.50; antihypertensive medication other than a RAS blocker or ß-blocker: HR: 1.67; 95% CI: 1.08-2.58). DISCUSSION: Our data suggested that the combination of a RAS blocker and a ß-blocker could improve survival in hemodialysis patients. Further prospective randomized controlled trials are necessary to confirm the beneficial effects of this combination of antihypertensive drugs in patients undergoing hemodialysis. (Elsevier, 2017)
  • Minimum standards on prevention, diagnosis and treatment of occupational and work-related skin diseases in Europe - position paper of the COST Action StanDerm (TD 1206)
    Alfonso, J.H.; Bauer, Andrea; Bensefa-Colas, L.; Boman, A.; Bubas, M.; Constandt, l.; Crepy, M. N.; Goncalo, M.; Macan, J.; Mahler, V.; Mijakoski, D.; Ramada Rodilla, José María, 1961-; Rustemeyer, T.; Spring, P.; John, S. M.; Uter, Wolfgang; Wilkinson, Mark; Giménez Arnau, Anna Maria (Wiley, 2017)
    BACKGROUND: Skin diseases constitute up to 40% of all notified occupational diseases in most European countries, predominantly comprising contact dermatitis, contact urticaria, and skin cancer. While insufficient prevention ...
  • Plasma Metabolites From Choline Pathway and Risk of Cardiovascular Disease in the PREDIMED (Prevention With Mediterranean Diet) Study
    Guasch Ferré, Marta; Hu, Frank B.; Ruiz-Canela, Miguel; Bulló, Mònica; Toledo, Estefania; Wang, Dong D.; Corella, Dolores; Gómez Gracia, Enrique; Fiol, Miquel; Estruch, Ramón; Lapetra, José; Fitó Colomer, Montserrat; Arós, Fernando; Serra-Majem, Luis; Ros, Emilio; Dennis, Courtney; Liang, Liming; Clish, Clary B.; Martínez-González, Miguel A.; Salas-Salvadó, Jordi (Wiley, 2017)
    BACKGROUND: The relationship between plasma concentrations of betaine and choline metabolism and major cardiovascular disease (CVD) end points remains unclear. We have evaluated the association between metabolites from the ...
  • Next generation of informatics tools for big data analytics in drug discovery
    Carrascosa Baena, María Carmen, 1972- (Universitat Pompeu Fabra, 2018-03-20)
    El paradigma clàssic on un medicament interacciona amb un únic target biològic vinculat a una malaltia es posa en dubte. Actualment es reconeix que un medicament interacciona amb múltiples targets biològics i que aquests ...
  • Addressing functional and evolutionary implications of microRNA variation at the DNA and RNA levels in primates
    Gallego Jiménez, Alicia, 1985- (Universitat Pompeu Fabra, 2016-11-14)
    microRNAs are small non-coding RNAs with crucial roles in gene regulation and whose contribution to animal evolution has been largely demonstrated. In this thesis we explored some functional consequences of microRNA sequence ...
  • Ionizing radiation biomarkers in epidemiological studies - An update
    Hall, Janet; Jeggo, Penny A.; West, Catharine; Gomolka, Maria; Quintens, Roel; Badie, Christophe; Laurent, Olivier; Aerts, Ann; Anastasov, Nataša; Azimzadeh, Omid; Azizova, Tamara; Baatout, Sarah; Baselet, Bjorn; Benotmane, Mohammed A.; Blanchardon, Eric; Guéguen, Yann; Haghdoost, Siamak; Harms-Ringhdahl, Mats; Hess, Julia; Kreuzer, Michaela; Laurier, Dominique; Macaeva, Ellina; Manning, Grain; Pernot, Eileen; Ravanat, Jean-Luc; Sabatier, Laure; Tack, Karine; Tapio, Soile; Zitzelsberger, Horst; Cardis, Elisabeth (Elsevier, 2017)
    Recent epidemiology studies highlighted the detrimental health effects of exposure to low dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown increased leukaemia and solid tumour ...