Cardiomyopathy and thrombogenesis in cats through left atrial morphological and fluid dynamics analysis

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• dc.contributor.author Pons Vidal, Maria Isabel
• dc.contributor.author Olivares, Andy L.
• dc.contributor.author Mill, Jordi
• dc.contributor.author Novo Matos, Jose
• dc.contributor.author García Cañadilla, Patricia, 1985-
• dc.contributor.author Cerrada, Inma
• dc.contributor.author Guy, Anna
• dc.contributor.author Morales Ferez, Xabier
• dc.contributor.author Hutchinson, John Ciaran
• dc.contributor.author Simcock, Ian C.
• dc.contributor.author Arthurs, Owen J.
• dc.contributor.author Cook, Andrew C.
• dc.contributor.author Luis Fuentes, Virginia
• dc.contributor.author Camara, Oscar
• dc.date.accessioned 2025-10-21T05:42:55Z
• dc.date.available 2025-10-21T05:42:55Z
• dc.date.issued 2025
• dc.description.abstract The relationship between atrial fibrillation (AF), blood flow disturbances and thrombus formation is well-established in humans. Thrombi primarily form in the left atrial appendage (LAA), but the specific role of LAA morphology remains unclear. Felines, despite rarely experiencing AF, present a valuable model for studying human heart diseases. Cats exhibit a high incidence of cardiomyopathies, often accompanied by significant left atrial dilation and thrombus formation. This unique aspect prompts research focusing on LAA morphology and function in relation to thrombus development. Our study, using advanced image processing and fluid simulations on 24 cat hearts ranging from normal to cardiomyopathy subjects, aims to find distinctions in left atrium (LA) and LAA morphologies, blood flow patterns and their relation to thrombus formation. Significantly different variables in feline heart groups included: heart weight, LAA volume, LA volume, ostium area, ostium area-to-heart weight ratio, centreline length and velocity at the LAA ostium. Fluid simulations revealed lower LAA blood flow velocities and increased thrombotic risk in cases with thrombi. Our study enhances the understanding of LAA structure and function, offering insights into thrombus formation mechanisms with potential implications for better managing thrombosis risk in patients.en
• dc.description.sponsorship This work was supported by the Agency for Management of University and Research Grants of the Generalitat de Catalunya under the Grants for the Contracting of New Research Staff Programme FI (2020 FI B 00608) and the Spanish Ministry of Economy and Competitiveness under the Programme for the Formation of Doctors (PRE2018-084062), the Maria de Maeztu Units of Excellence Programme (MDM-2015-0502) and the Retos Investigación projects VIROLAAI and GENERALITAAT (RTI2018-101193-B-I00, PID2022-143239OB-I00). Furthermore, this work was supported by the H2020 EU SimCardioTest project (Digital transformation in Health and Care SC1-DTH-06-2020; Grant agreement No. 101016496).en
• dc.format.mimetype application/pdf
• dc.identifier.citation Pons MI, Olivares AL, Mill J, Matos JN, Garcia-Canadilla P, Cerrada I, et al. Cardiomyopathy and thrombogenesis in cats through left atrial morphological and fluid dynamics analysis. Sci Rep. 2025 Apr 10;15(1):12263. DOI: 10.1038/s41598-025-96245-7
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-025-96245-7
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/71586
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Scientific Reports. 2025 Apr 10;15(1):12263
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101016496
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-143239OB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-101193-B-I00
• dc.rights © The Author(s) 2025. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.other Cardiologiaca
• dc.subject.other Enginyeria biomèdicaca
• dc.subject.other Enginyeriaca
• dc.title Cardiomyopathy and thrombogenesis in cats through left atrial morphological and fluid dynamics analysisen
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion