From chronic obstructive pulmonary disease to lung cancer : an immunologic approach
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Document Version
Author
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Barreiro Portela, Esther
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Publication Date
Pages
175 p.
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Citation
Ramis Cabrer, D. From chronic obstructive pulmonary disease to lung cancer : an immunologic approach. Universitat Pompeu Fabra; 2019. handle: http://hdl.handle.net/10803/667310
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Doctoral program
Programa de doctorat en Biomedicina
Abstract
Se ha establecido que un subconjunto de pacientes con cáncer debuta con infiltrados inmunes que se organizan en agregados en el nicho tumoral y sus alrededores. Estas estructuras linfoides se desarrollan en respuesta a estímulos inflamatorios a través de un proceso estrechamente regulado. Además de su valor pronóstico, las TLSs pueden representar una nueva vía para las estrategias terapéuticas, pero actualmente se encuentra en etapas iniciales. En contraste con el papel en la activación inmune de las TLSs, en ciertos tumores, su efecto puede apuntar hacia la progresión tumoral como consecuencia de las condiciones altamente inmunosupresoras mediadas por las células malignas presentes en el nicho tumoral. Los datos preliminares proporcionados por la siguiente investigación sugieren que los pacientes con cáncer de pulmón podrían presentar un perfil inmunitario diferencial respecto a estos mismos que además subyacen EPOC. Este hecho podría presentar un impacto potencial en el pronóstico y la terapia de estos pacientes. Por otra parte, resultados procedentes de la actual investigación también revelan que ciertos marcadores cruciales presentes en diferentes vías de señalización involucradas con el estrés oxidativo, la apoptosis y la autofagia podría sobre expresarse en respuesta a la administración de inmunomoduladores. Estos datos ponen de manifiesto el interés de mecanismos adicionales relacionados con la inmunidad que podrían ser manipulados para asistir a la inmunidad contra el cáncer.
It is well established that a subset of cancer patients debuts with immune infiltrates, which organize into aggregates in the tumor niche and its vicinity. These lymphoid structures develop in response to inflammatory stimuli through a tightly regulated process. Besides the prognostic value of TLSs, they also may represent a novel avenue for therapeutic strategies, but it is currently still in its early stages. In contrast with the immune activator role of TLSs, in certain cancers, its effect may point towards tumor progression as a consequence of highly tumor-mediated immunosuppressive conditions present in the tumor niche. Preliminary data provided by the current investigation suggests that a differential immune profile may be present between LC patients and LC patients underlying COPD. This fact could present a potential impact in the prognosis and therapy of these patients. Moreover, crucial markers targeting different signaling pathways involved with oxidative stress, apoptosis, and autophagy were found to be overexpressed in response to immunomodulators administration in the current thesis. These data puts into manifest the interest of additional immunity-related mechanisms that could be targeted in order to assist immunity against cancer.
It is well established that a subset of cancer patients debuts with immune infiltrates, which organize into aggregates in the tumor niche and its vicinity. These lymphoid structures develop in response to inflammatory stimuli through a tightly regulated process. Besides the prognostic value of TLSs, they also may represent a novel avenue for therapeutic strategies, but it is currently still in its early stages. In contrast with the immune activator role of TLSs, in certain cancers, its effect may point towards tumor progression as a consequence of highly tumor-mediated immunosuppressive conditions present in the tumor niche. Preliminary data provided by the current investigation suggests that a differential immune profile may be present between LC patients and LC patients underlying COPD. This fact could present a potential impact in the prognosis and therapy of these patients. Moreover, crucial markers targeting different signaling pathways involved with oxidative stress, apoptosis, and autophagy were found to be overexpressed in response to immunomodulators administration in the current thesis. These data puts into manifest the interest of additional immunity-related mechanisms that could be targeted in order to assist immunity against cancer.
Keywords
Cáncer de pulmón, EPOC, Inmunosupresión, Estrés oxidativo, Autofagia, Lung cancer, COPD, Immunosuppresion, Oxidative stress, Autophagy
Subjects
616.2 - Pathology of the respiratory system
Publisher
Universitat Pompeu Fabra
