Human leukocyte antigen class I expression and natural killer cell infiltration and its correlation with prognostic features in luminal breast cancers

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• dc.contributor.author Vernet-Tomás, Maria
• dc.contributor.author Vázquez, Ivonne
• dc.contributor.author Olivares, Francesc
• dc.contributor.author Lopez, David
• dc.contributor.author Yélamos López, José
• dc.contributor.author Comerma Blesa, Laura, 1983-
• dc.date.accessioned 2025-10-22T17:23:33Z
• dc.date.available 2025-10-22T17:23:33Z
• dc.date.issued 2024
• dc.date.updated 2025-10-22T17:23:33Z
• dc.description.abstract Purpose: The aim of this study was to determine whether low HLA-I expression and NK cells infiltration are related to prognostic features in breast cancer, as observed in cancers in other locations and non-hormone dependent breast cancers. Particularly, we explored their relation to infiltrated axillary lymph nodes (ALNs), with the aim of finding new predictors helping to decide the extent of axillary surgery. Patients and methods: We conducted a retrospective correlational analysis of 35 breast cancers from 35 breast cancer patients showing axillary infiltration at diagnosis and with upfront surgery. HLA-I H-score and the number of NK cells x 50 high power fields (HPF) in the biopsy specimen were correlated with pathological variables of the surgical specimen: number of infiltrated ALNs, tumor size, histological type, the presence of ductal carcinoma in situ, focality, histological grade, necrosis, lymphovascular and perineural invasion, Her2Neu status, and the percentages of tumor-infiltrating lymphocytes (TILs), estrogen receptor, progesterone receptor, ki67, and p53. Results: All tumors showed hormone receptor expression and three of them Her2Neu positivity. A positive correlation (p=0.001**) was found between HLA-I H-score and TILs and Ki67 expression. HLA H-score increased with histological grade and was higher in unifocal than in multifocal disease (p=0.044 and p=0.011, respectively). No other correlations were found. Conclusion: High HLA-I H-score values correlated with features of poor prognosis in this cohort of luminal breast tumors, but not with infiltrated ALNs. This finding highlights the differences between luminal breast cancer, and cancers in other locations and non-hormone dependent breast cancers, in which low HLA-I expression tends to be associated with poor prognostic features.
• dc.format.mimetype application/pdf
• dc.identifier.citation Vernet-Tomas M, Vazquez I, Olivares F, Lopez D, Yelamos J, Comerma L. Human leukocyte antigen class I expression and natural killer cell infiltration and its correlation with prognostic features in luminal breast cancers. Breast Cancer (Dove Med Press). 2024 Oct 5:16:657-66. DOI: 10.2147/BCTT.S476721
• dc.identifier.doi http://dx.doi.org/10.2147/BCTT.S476721
• dc.identifier.issn 1179-1314
• dc.identifier.uri http://hdl.handle.net/10230/71634
• dc.language.iso eng
• dc.publisher Dove Medical Press
• dc.relation.ispartof Breast Cancer: Targets and Therapy. 2024;16:657-66
• dc.rights © 2024 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, 3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
• dc.subject.keyword HLA-I
• dc.subject.keyword Axillary lymph nodes
• dc.subject.keyword Luminal breast cancer
• dc.subject.keyword Natural killer cells
• dc.subject.keyword Prognostic features
• dc.title Human leukocyte antigen class I expression and natural killer cell infiltration and its correlation with prognostic features in luminal breast cancers
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion