Transcriptional and post-transcriptional regulation across biological units and time

Sodaei, Reza

Transcriptional and post-transcriptional regulation across biological units and time

Document Type

Doctoral thesis
Published Version

Author

Sodaei, Reza

Director

Guigó Serra, Roderic
Irimia Martínez, Manuel

Publication Date

2020-05-22

Pages

88 p.

Citation

Sodaei, R. Transcriptional and post-transcriptional regulation across biological units and time. Universitat Pompeu Fabra; 2020. handle: http://hdl.handle.net/10803/669533

This citation was generated automatically.

Doctoral program

Programa de doctorat en Biomedicina

Abstract

How do genomes generate different tissues, behaviours, individuals or species? We try to identify parts of the human transcriptome that we found only in a tissue. Then, we focus on inter-individual extreme transcriptomic differences, and how this principle is extendable to species variation. In the second part, we measured the transcriptomic shifts during day-night and seasonal cycles in human postmortem tissues.
Com generen diferents genomes diferents teixits, conductes, individus o espècies? Tractem d'identificar parts del transcriptoma humà que hem trovat només en un teixit. Seguidament, ens centrem en diferències transcriptòmices extremes entre individus, i en com aquest principi es pot extendre a les variacions de espècie. Al segon capítol, mesurem els canvis transcriptòmics durant cicles de dia i nit així com estacionals en teixits humans postmortem.