Cardiopulmonary exercise testing with simultaneous echocardiography after pulmonary embolism

Khilzi, Karys; Piccari, Lucilla; Franco, Gerard; Rodó-Pin, Anna; Herranz Blasco, Anna; Blanco, Isabel; Paciocco, Giuseppe; Volpiano, Lorenzo; Gonzalez Garcia, Jose Gregorio; Diez-Llaneza, Ana; Molina Ferragut, Luis; Rodríguez Chiaradia, Diego Agustín

doi:http://dx.doi.org10.1002/pul2.70045

Cardiopulmonary exercise testing with simultaneous echocardiography after pulmonary embolism

License

Citation

Khilzi K, Piccari L, Franco G, Rodó-Pin A, Herranz A, Blanco I, Paciocco G, Volpiano L, Gonzalez Garcia J, Diez-Llaneza A, Molina L, Rodríguez Chiaradía DA. Cardiopulmonary exercise testing with simultaneous echocardiography after pulmonary embolism. Pulm Circ. 2025 Feb 5;15(1):e70045. DOI: 10.1002/pul2.70045

Abstract

Although current guidelines recommend standard cardiopulmonary exercise testing (CPET) to evaluate symptomatic patients after pulmonary embolism (PE), CPET with simultaneous echocardiography could provide relevant information to evaluate right ventricular-pulmonary arterial coupling. The aim of this study was to investigate exercise-induced changes in echocardiographic variables of RV function or RV- arterial coupling in patients with residual thrombotic defects at 3 months after PE. This retrospective study investigated patients with residual thromboembolic disease on V/Q scintigraphy with persistent symptoms despite adequate anticoagulation after 3 months of acute PE, and resting echocardiography with a low probability of PH. At rest and during exercise, CPET and doppler echocardiography were performed following a standard protocol. Forty-five patients were included, completing a follow-up period of at least 24 months. The mean (standard deviation) age was 63 (15) years, and 24 (53%) patients were male. Four patients developed CTEPH after 2 years follow up. Correlation analyses showed that the peak TAPSE was significantly associated with peak workload (r = 0.454, p = 0.003), peak VO2 (r = 0.558, p < 0.001), VE/VECO2 (AT) (r = -0.531, p < 0.001), and oxygen pulse (r = 0.375, p = 0.02). TAPSE/PASP was only slightly associated with peak workload (r = 0.300, p = 0.045). By contrast, the change on TAPSE (from rest to peak) was significantly correlate with peak oxygen uptake (r = 0.491, p = 0.01). Also, reduced VO2 at AT and TAPSE/PASP was seen in patients with CTEPH. CPET with synchronic echocardiography could be a useful tool in early assessment of symptomatic patients with perfusion defects on imaging after 3 months of correctly treated PE.