Improving the prediction of the functional impact of cancer mutations by baseline tolerance transformation

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• dc.contributor.author González-Pérez, Abelca
• dc.contributor.author Déu Pons, Jordica
• dc.contributor.author López Bigas, Núriaca
• dc.date.accessioned 2013-11-28T11:32:13Z
• dc.date.available 2013-11-28T11:32:13Z
• dc.date.issued 2012ca
• dc.description.abstract High-throughput prioritization of cancer-causing mutations (drivers) is a key challenge of cancer genome projects, due to the number of somatic variants detected in tumors. One important step in this task is to assess the functional impact of tumor somatic mutations. A number of computational methods have been employed for that purpose, although most were originally developed to distinguish disease-related nonsynonymous single nucleotide variants (nsSNVs) from polymorphisms. Our new method, transformed Functional Impact score for Cancer (transFIC), improves the assessment of the functional impact of tumor nsSNVs by taking into account the baseline tolerance of genes to functional variants.en
• dc.description.sponsorship We acknowledge funding from the Spanish Ministry of Science and Technology (grant number SAF2009-06954) and the Spanish National Institute of Bioinformatics (INB).en
• dc.format.mimetype application/pdfca
• dc.identifier.citation Gonzalez-Perez A, Deu-Pons J, López-Bigas N. Improving the prediction of the functional impact of cancer mutations by baseline tolerance transformation. Genome Med. 2012;4(11):89. DOI: 10.1186/gm390ca
• dc.identifier.doi http://dx.doi.org/10.1186/gm390
• dc.identifier.issn 1756-994Xca
• dc.identifier.uri http://hdl.handle.net/10230/21311
• dc.language.iso engca
• dc.publisher BioMed Centralca
• dc.relation.ispartof Genome Medicine. 2012;4(11):89
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2009-06954
• dc.rights © Gonzalez-Perez et al. Creative Commons Attribution Licenseca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by/2.0/
• dc.title Improving the prediction of the functional impact of cancer mutations by baseline tolerance transformationca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca