Multicenter study of parenteral nutrition in non-critically ill elderly patients compared to younger patients - Study IAIOS-PN (Incidence and Assessment of Iatrogenesis in Older Subjects receiving Parenteral Nutrition)

Mateu de Antonio, Francisco Javier; Berlana, David; Pons-Busom, Montserrat; Badia-Tahull, Maria B.; Miana-Mena, María Teresa; Martínez-Castro, Beatriz; Sunyer-Esquerrà, Neus; Sanmartin-Suñer, Mónica; González-Valdivieso, Juan; Leiva-Badosa, Elisabet; Martínez-Bernabé, Eva; Murgadella-Sancho, Anna; Mirerachs-Aranda, Nuria; Vila-Bundó, Anna; Fernández-Morató, Jordi; Vitales-Farrero, María Teresa

doi:http://dx.doi.org/10.20960/nh.1393

Multicenter study of parenteral nutrition in non-critically ill elderly patients compared to younger patients - Study IAIOS-PN (Incidence and Assessment of Iatrogenesis in Older Subjects receiving Parenteral Nutrition)

Citation

Mateu-de Antonio J, Berlana D, Pons-Bussom M, Badia-Tahull MB, Miana-Mena MT, Martínez-Castro B, et al. Multicenter study of parenteral nutrition in non-critically ill elderly patients compared to younger patients -Study IAIOS-PN (Incidence and Assessment of Iatrogenesis in Older Subjects receiving Parenteral Nutrition). Nutr Hosp. 2018 Feb 27;35(2):252-258. DOI: 10.20960/nh.1393

Abstract

OBJECTIVE: this study assessed the incidence of hyperglycemia, hypertriglyceridemia, and liver function test (LFT) alterations among patients older and younger than 65 years receiving parenteral nutrition (PN). A secondary objective was to compare the incidence of any of these three events. MATERIAL AND METHODS: inclusion criteria were non-critically ill adult inpatients receiving PN for ≥ 7 days in 15 hospitals in Spain. Exclusion criteria were hyperglycemia, hypertriglyceridemia, LFT alterations, sepsis, shock, pancreatic/hepatobiliary surgery, renal failure, diabetes mellitus (DM) type 1, insulin-treated DM type 2, acute DM complications, or obesity prior to PN. Patients were classified into groups YOUNG (aged 35-64) and OLD (aged 65-95). RESULTS: this study recruited 200 patients. Group YOUNG included 63 (31.5%) patients and OLD, 137 (68.5%). Hyperglycemia appeared in 37 (18.5%) patients, eight (12.7%) in group YOUNG and 29 (21.2%) in group OLD (p = 0.174). Hypertriglyceridemia appeared in only one (0.7%) patient. LFT alterations appeared in 141 (70.5%) patients, 44 (69.8%) in group YOUNG and 97 (70.8%) in group OLD (p = 1.000). The model for hyperglycemia included DM type 2, previous surgical procedure, and use of hyperglycemia-inducing medications. The model for LFT alteration included previous surgical procedure, amount of lipids and amino acids, medications causing LFT alterations and a trend for age group. The model for any event included surgical procedure, DM type 2, and medications causing alterations. CONCLUSION: patients of ≥ 65 years receiving PN had similar incidences of hyperglycemia, hypertriglyceridemia, and LFT alterations as younger patients. Additionally, older patients had trends toward lower LFT alterations.