Revealing the relevant spatiotemporal scale underlying whole-brain dynamics

Kobeleva, Xenia; López-González, Ane, 1993-; Kringelbach, Morten L.; Deco, Gustavo

doi:http://doi.org/10.3389/fnins.2021.715861

Revealing the relevant spatiotemporal scale underlying whole-brain dynamics

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Kobeleva X, López-González A, Kringelbach ML, Deco G. Revealing the relevant spatiotemporal scale underlying whole-brain dynamics. Front Neurosci. 2021;15:715861. DOI: 10.3389/fnins.2021.715861

Abstract

The brain rapidly processes and adapts to new information by dynamically transitioning between whole-brain functional networks. In this whole-brain modeling study we investigate the relevance of spatiotemporal scale in whole-brain functional networks. This is achieved through estimating brain parcellations at different spatial scales (100– 900 regions) and time series at different temporal scales (from milliseconds to seconds) generated by a whole-brain model fitted to fMRI data. We quantify the richness of the dynamic repertoire at each spatiotemporal scale by computing the entropy of transitions between whole-brain functional networks. The results show that the optimal relevant spatial scale is around 300 regions and a temporal scale of around 150 ms. Overall, this study provides much needed evidence for the relevant spatiotemporal scales and recommendations for analyses of brain dynamics.