Molecular and functional characterization of irem-3, a new activating member of the cmrf/irem family

Martínez Barriocanal, Agueda

Molecular and functional characterization of irem-3, a new activating member of the cmrf/irem family

Document Type

Doctoral thesis
Published Version

Author

Martínez Barriocanal, Agueda

Director

Sayós Ortega, Juan

Publication Date

2009-04-16

Citation

Martínez Barriocanal, A. Molecular and functional characterization of irem-3, a new activating member of the cmrf/irem family. Universitat Pompeu Fabra; 2009. handle: http://hdl.handle.net/10803/7159

This citation was generated automatically.

Doctoral program

Programa de doctorat en Biomedicina

Abstract

En los últimos años hemos sido testigos de la identificación de múltiples familias de receptores inmunológicos. En este contexto encontramos la recientemente descrita familia IREM/CD300 localizada en la región cromosómica 17q25.1 y restringida en expresión a las células de origen mieloide. El locus humano se compone de dos genes codificantes para receptores con propiedades inhibidoras (IRp60/CD300a y IREM-1/CD300f), dos genes codificantes para receptores con naturaleza activadora (IREM-2/CD300e y IREM-3/CD300b) y dos genes codificantes para receptores con características que no permiten su inclusión en ninguno de los anteriores grupos (CMRF-35/CD300c i IREM-4/CD300d). El presente trabajo describimos la caracterización molecular del receptor IREM-3/CD300b, las vías de señalización intracelular utilizadas por esta molécula y la relación funcional existente entre los diferentes miembros pertenecientes a la familia IREM/CD300.
In the last years, different multigenic families of immune receptors have been identified. In this context, we find the recently described IREM/CD300 family of immune receptors which maps in the 17q25.1 chromosomical region and is restricted in expression to the cells with a myeloid origin. The human locus is composed by two genes encoding for inhibitory receptors (IRp60/CD300a and IREM-1/CD300f), two genes encoding for activating receptors (IREM-2/CD300e and IREM-3/CD300b) and two genes encoding for receptors with features that make its classification uncertain (CMRF-35/CD300c and IREM-4/CD300d). In the present work we describe the molecular characterization of IREM-3/CD300b receptor, the dissection of the intracellular signaling pathways engaged by this molecule and the functional relationship between the different IREM/CD300 family members.