Decoding pulmonary embolism: pathophysiology, diagnosis, and treatment

Peracaula, Miriam; Sebastian, Laura; Francisco, Iria; Bonnin Vilaplana, Marc; Rodríguez Chiaradia, Diego Agustín; Tura-Ceide, Olga

doi:http://dx.doi.org/10.3390/biomedicines12091936

Decoding pulmonary embolism: pathophysiology, diagnosis, and treatment

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Peracaula M, Sebastian L, Francisco I, Bonnin Vilaplana M, Rodríguez-Chiaradía DA, Tura-Ceide O. Decoding pulmonary embolism: pathophysiology, diagnosis, and treatment. Biomedicines. 2024;12(9):1936. DOI: 10.3390/biomedicines12091936

Abstract

Pulmonary Embolism (PE) is a life-threatening condition initiated by the presence of blood clots in the pulmonary arteries, leading to severe morbidity and mortality. Underlying mechanisms involve endothelial dysfunction, including impaired blood flow regulation, a pro-thrombotic state, inflammation, heightened oxidative stress, and altered vascular remodeling. These mechanisms contribute to vascular diseases stemming from PE, such as recurrent thromboembolism, chronic thromboembolic pulmonary hypertension, post-thrombotic syndrome, right heart failure, and cardiogenic shock. Detailing key risk factors and utilizing hemodynamic stability-based categorization, the review aims for precise risk stratification by applying established diagnostic tools and scoring systems. This article explores both conventional and emerging biomarkers as potential diagnostic tools. Additionally, by synthesizing existing knowledge, it provides a comprehensive outlook of the current enhanced PE management and preventive strategies. The conclusion underscores the need for future research to improve diagnostic accuracy and therapeutic effectiveness in PE.