• Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis

  Al-Refaie, Nada; Padovani, Francesco; Hornung, Johanna; Pudelko, Lorenz; Binando, Francesca; Carmen Fabregat, Andrea del; Zhao, Qiuxia; Towbin, Benjamin D.; Sarinay Cenik, Elif; Stroustrup, Nicholas; Padeken, Jan; Schmoller, Kurt M.; Cabianca, Daphne S. (Nature Research, 2024)

  Chromatin architecture is a fundamental mediator of genome function. Fasting is a major environmental cue across the animal kingdom, yet how it impacts three-dimensional (3D) genome organization is unknown. Here we show ...
• The genetic architecture of protein stability

  Faure, Andre J.; Martí Aranda, Aina; Hidalgo-Carcedo, Cristina; Beltran, Antoni; Schmiedel, Jörn M.; Lehner, Ben, 1978- (Nature Research, 2024)

  There are more ways to synthesize a 100-amino acid (aa) protein (20100) than there are atoms in the universe. Only a very small fraction of such a vast sequence space can ever be experimentally or computationally surveyed. ...
• High-resolution kinetics and cellular determinants of SARS-CoV-2 antibody response over two years after COVID-19 vaccination

  Rubio, Rocío; Macià, Dídac; Barrios, Diana; Vidal, Marta; Jiménez, Alfons; Molinos-Albert, Luis M.; Díaz, Natalia; Canyelles, Mar; Lara Escandell, Maria; Planchais, Cyril; Santamaria, Pere; Carolis, Carlo; Izquierdo, Luis; Aguilar, Ruth; Moncunill, Gemma; Dobaño, Carlota (Elsevier, 2024)

  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) studies usually rely on cross-sectional data of large cohorts but limited repeated samples, overlooking significant inter-individual antibody kinetic differences. ...
• Surface conversion of the dynamics of bacteria escaping chemorepellents

  Braham, Asma; Lemelle, Laurence; Ducasse, Romain; Toukabri, Houyem; Mottin, Eleonore; Fabrèges, Benoit; Calvez, Vincent; Place, Christophe (Springer, 2024)

  Flagellar swimming hydrodynamics confers a recognized advantage for attachment on solid surfaces. Whether this motility further enables the following environmental cues was experimentally explored. Motile E. coli (OD ~ ...
• The relationship between nanoscale genome organization and gene expression in mouse embryonic stem cells during pluripotency transition

  Garate,, Ximena; Gómez García, Pablo Aurelio; Fernández Merino, Manuel; Cadevall Anglès, Marta; Zhu, Chenggan; Castells García, Àlvaro, 1991-; Ed-Daoui, Ilyas; Martin, Laura; Ochiai, Hiroshi; Neguembor, Maria Victoria; Cosma, Maria Pia (Oxford University Press, 2024)

  During early development, gene expression is tightly regulated. However, how genome organization controls gene expression during the transition from naïve embryonic stem cells to epiblast stem cells is still poorly understood. ...
• A deep learning method that identifies cellular heterogeneity using nanoscale nuclear features

  Carnevali, Davide; Zhong, Limei; González-Almela, Esther; Viana, Carlotta; Rotkevich, Mikhail; Wang, Aiping; Franco-Barranco, Daniel; González-Marfil, Aitor; Neguembor, Maria Victoria; Castells García, Àlvaro, 1991-; Arganda-Carreras, Ignacio; Cosma, Maria Pia (Springer, 2024)

  Cellular phenotypic heterogeneity is an important hallmark of many biological processes and understanding its origins remains a substantial challenge. This heterogeneity often reflects variations in the chromatin structure, ...
• Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules

  Toledano, Ignasi; Supek, Fran; Lehner, Ben (Nature Research, 2024)

  Premature termination codons (PTCs) cause ~10-20% of inherited diseases and are a major mechanism of tumor suppressor gene inactivation in cancer. A general strategy to alleviate the effects of PTCs would be to promote ...
• What’s in a name? A large-scale computational study on how competition between names affects naming variation

  Gualdoni, Eleonora; Brochhagen, Thomas; Mädebach, Andreas; Boleda, Gemma (Elsevier, 2023)

  Different speakers often use different names to refer to the same entity (e.g., “woman” vs. “tennis player” for a given woman playing tennis). We study how visual typicality affects variation in naming behavior. We use a ...
• Five decades of occupational cancer epidemiology

  Turner, Michelle C.; Straif, Kurt; Kogevinas, Manolis; Schubauer-Berigan, Mary K. (Nordic Association of Occupational Safety and Health (NOROSH), 2024)

  Objective: In this discussion paper, we provide a narrative review of past and present occupational cancer studies in the journal with a viewpoint towards future occupational cancer research. Method: We reviewed all ...
• Linguistic markers of psychosis in Mandarin Chinese: relations to theory of mind

  Zhang, Han; Parola, Alberto; Zhou, Yuan; Wang, Huiling Wang; Bliksted Vibeke; Fusaroli, Riccardo; Hinzen, Wolfram (Elsevier, 2023)

  Disorganized and impoverished language is a key feature of schizophrenia (Sz), but whether and which linguistic changes previously observed in Indo-European languages generalize to other languages remains unclear. Targeting ...
• Natural language processing markers for psychosis and other psychiatric disorders: emerging themes and research agenda from a cross-linguistic workshop

  Corona Hernández, Hugo; Hinzen, Wolfram; Palaniyappan, Lena (Oxford University Press, 2023)

  This workshop summary on natural language processing (NLP) markers for psychosis and other psychiatric disorders presents some of the clinical and research issues that NLP markers might address and some of the activities ...
• Development of land use regression, dispersion, and hybrid models for prediction of outdoor air pollution exposure in Barcelona

  Domínguez, Alan; Dadvand, Payam; Cirach, Marta; Gascon Merlos, Mireia, 1984-; Raimbault, Bruno; Galmés, Toni; Goméz Herrera, Laura; Persavento, Cecilia; Samuelsson, Karl; Tonne, Cathryn; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi; Basagaña Flores, Xavier; Rivas, Ioar (Elsevier, 2024)

  Background: Air pollution is the leading environmental risk factor for health. Assessing outdoor air pollution exposure with detailed spatial and temporal variability in urban areas is crucial for evaluating its health ...
• Sex/gender effects of glial reactivity on preclinical Alzheimer's disease pathology

  Vila-Castelar, Clara; Akinci, Muge; Palpatzis, Eleni; Aguilar Dominguez, Pablo; Operto, Grégory; Kollmorgen, Gwendlyn; Quijano Rubio, Clara; Blennow, Kaj; Zetterberg, Henrik; Falcón, Carles; Fauria, Karine; Gispert López, Juan Domingo; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Arenaza Urquijo, Eider M.; ALFA Study (Nature Research, 2024)

  Glial reactivity may contribute to sex/gender differences in Alzheimer's disease (AD) pathophysiology. Here, we investigated the differential effect of cerebrospinal fluid (CSF) glial markers on AD pathology and neurodegeneration ...
• Unbiased temperature-related mortality estimates using weekly and monthly health data: a new method for environmental epidemiology and climate impact studies

  Basagaña Flores, Xavier; Ballester, Joan (Elsevier, 2024)

  Background: Exposure to environmental factors has a high burden on human health, with millions of premature annual deaths associated with the short-term health effects of ambient temperatures and air pollution. However, ...
• Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth

  Knox, Bethany; Güil Oumrait, Núria; Basagaña Flores, Xavier; Cserbik, Dora; Dadvand, Payam; Foraster Pulido, Maria, 1984-; Galmes, Toni; Gascon Merlos, Mireia, 1984-; Gómez-Roig, María Dolores; Gómez Herrera, Laura C.; Haug, Line Småstuen; Llurba, Elisa; Márquez, Sandra; Rivas, Ioar; Sunyer Deu, Jordi; Thomsen, Cathrine; Zanini, Maria Julia; Bustamante Pineda, Mariona; Vrijheid, Martine (Elsevier, 2024)

  Introduction: The impact of legacy per- and polyfluoroalkyl substances (PFAS) on fetal growth has been well studied, but assessments of next-generation PFAS and PFAS mixtures are sparse and the potential role of fetoplacental ...
• Gestational organophosphate pesticide exposure and childhood cardiovascular outcomes

  Stevens, Danielle R.; Blaauwendraad, Sophia M.; Bommarito, Paige A.; van den Dries, Michiel; Trasande, Leonardo; Spaan, Suzanne; Pronk, Anjoeka; Tiemeier, Henning; Gaillard, Romy; Jaddoe, Vincent W. V.; Ferguson, Kelly K. (Elsevier, 2024)

  Introduction: The general population is chronically exposed to organophosphate pesticides through various routes including ingestion, hand-to-mouth contact, inhalation, and dermal contact. Exposure to organophosphate ...
• Exploring the pathways linking prenatal and early childhood greenness exposure to attention-deficit/hyperactivity disorder symptoms during childhood: An approach based on robust causal inference

  Luque-García, Leire; García-Baquero, Gonzalo; Lertxundi, Aitana; Al-Delaimy, Wael K.; Julvez, Jordi; Estarlich, Marisa; de Castro, Montserrat; Guxens Junyent, Mònica; Lozano, Manuel; Subiza-Pérez, Mikel; Ibarluzea, Jesús (Elsevier, 2024)

  Background: Epidemiological studies suggest that exposure to greenness during childhood may protect children from developing attention-deficit hyperactivity disorder (ADHD). Objective: We analyzed the effect of both prenatal ...
• Social inequalities in child mental health trajectories: a longitudinal study using birth cohort data 12 countries

  Cadman, Tim; Guxens Junyent, Mònica; Julvez, Jordi; Strandberg-Larsen, Katrine (BioMed Central, 2024)

  Background: Social inequalities in child mental health are an important public health concern. Whilst previous studies have examined inequalities at a single time point, very few have used repeated measures outcome data ...
• Evaluating the association between placenta DNA methylation and cognitive functions in the offspring

  Diez-Ahijado, Laia; Cilleros-Portet, Ariadna; Fernández-Jiménez, Nora; Fernández, Mariana F.; Guxens Junyent, Mònica; Julvez, Jordi; Llop, Sabrina; Lopez-Espinosa, Maria-José; Subiza-Pérez, Mikel; Lozano, Manuel; Ibarluzea, Jesús; Sunyer Deu, Jordi; Bustamante Pineda, Mariona; Cosín Tomàs, Marta (Nature Research, 2024)

  The placenta plays a crucial role in protecting the fetus from environmental harm and supports the development of its brain. In fact, compromised placental function could predispose an individual to neurodevelopmental ...
• Socioeconomic position during pregnancy and pre-school exposome in children from eight European birth cohort studies

  Pizzi, Costanza; Vrijheid, Martine; Fossati, Serena; Nieuwenhuijsen, Mark J.; Richiardi, Lorenzo (Elsevier, 2024)

  Distribution of environmental hazards and vulnerability to their effects vary across socioeconomic groups. Our objective was to analyse the relationship between child socioeconomic position (SEP) at birth and the external ...

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