• The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development

  Nakagawa, Shoma; Carnevali, Davide; Tan, Xiangtian; Alvarez, Mariano J.; Parfitt, David-Emlyn; Di Vicino, Umberto; Arumugam, Karthik; Shin, William; Aranda, Sergi; Normanno, Davide; Sebastián Pérez, Rubén; Cannatá, Chiara; Cortes, Paola; Neguembor, Maria Victoria; Shen, Michael M.; Califano, Andrea; Cosma, Maria Pia (Elsevier, 2024)

  Embryo size, specification, and homeostasis are regulated by a complex gene regulatory and signaling network. Here we used gene expression signatures of Wnt-activated mouse embryonic stem cell (mESC) clones to reverse ...
• TANGO1 inhibitors reduce collagen secretion and limit tissue scarring

  Raote, Ishier; Häkkinen, Hanna-Maria; Vibe, Carine; Broadbent, Katrina; Carolis, Carlo; Ruprecht, Verena; Malhotra, Vivek (Nature Research, 2024)

  Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis and compromise tissue function. Despite the widespread occurrence of fibrotic diseases and scarring, effective therapies ...
• Active transcription and epigenetic reactions synergistically regulate meso-scale genomic organization

  Kant, Aayush; Guo, Zixian; Vinayak, Vinayak; Neguembor, Maria Victoria; Li, Wing Shun; Agrawal, Vasundhara; Pujadas, Emily; Almassalha, Luay; Backman, Vadim; Lakadamyali, Melike; Cosma, Maria Pia; Shenoy, Vivek B. (Nature Research, 2024)

  In interphase nuclei, chromatin forms dense domains of characteristic sizes, but the influence of transcription and histone modifications on domain size is not understood. We present a theoretical model exploring this ...
• Engineering Mycoplasma pneumoniae to bypass the association with Guillain-Barré syndrome

  Broto, Alicia; Piñero-Lambea, Carlos; Segura-Morales, Carolina; Tio-Gillen, Anne P.; Unger, Wendy W. J.; Burgos, Raul; Mazzolini, Rocco; Miravet Verde, Samuel; Jacobs, Bart C.; Casas, Josefina; Huizinga, Ruth; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Elsevier, 2024)

  A non-pathogenic Mycoplasma pneumoniae-based chassis is leading the development of live biotherapeutic products (LBPs) for respiratory diseases. However, reports connecting Guillain-Barré syndrome (GBS) cases to prior M. ...
• Systematic mapping of organism-scale gene-regulatory networks in aging using population asynchrony

  Eder, Matthias; Martin, Olivier M. F.; Oswal, Natasha; Sedlackova, Lucia; Moutinho, Catia; Carmen Fabregat, Andrea del; Menéndez Bravo, Simón; Sebé-Pedrós, Arnau; Heyn, Holger; Stroustrup, Nicholas (Elsevier, 2024)

  In aging, physiologic networks decline in function at rates that differ between individuals, producing a wide distribution of lifespan. Though 70% of human lifespan variance remains unexplained by heritable factors, little ...
• Characterization of the common genetic variation in the spanish population of Navarre

  Maillo, Alberto; Beltran, Sergi; Gómez Cabrero, David (MDPI, 2024)

  Large-scale genomic studies have significantly increased our knowledge of genetic variability across populations. Regional genetic profiling is essential for distinguishing common benign variants from disease-causing ones. ...
• Childhood exposure to outdoor air pollution in different microenvironments and cognitive and fine motor function in children from six European cohorts

  Domínguez, Alan; Koch, Sarah; Márquez, Sandra; Castro, Montserrat de; Urquiza, José M.; Evandt, Jorunn; Oftedal, Bente; Aasvang, Gunn Marit; Kampouri, Mariza; Vafeiadi, Marina, 1983-; Mon-Williams, Mark; Lewer, Dan; Lepeule, Johanna; Andrušaitytė, Sandra; Vrijheid, Martine; Guxens Junyent, Mònica; Nieuwenhuijsen, Mark J. (Elsevier, 2024)

  Background: Exposure to air pollution during childhood has been linked with adverse effects on cognitive development and motor function. However, limited research has been done on the associations of air pollution exposure ...
• Urban green spaces and behavioral and cognitive development in children: a health impact assessment of the Barcelona "Eixos Verds" Plan (Green Axis Plan)

  Opbroek, Jet; Pereira Barboza, Evelise; Nieuwenhuijsen, Mark J.; Dadvand, Payam; Mueller, Natalie, 1988- (Elsevier, 2024)

  Background: Urban environments lack natural features, while nature exposure in cities has been associated with health benefits, including children's neurodevelopment. Through extensive street greening, Barcelona's Eixos ...
• Cohort Profile: Barcelona Life Study Cohort (BiSC)

  Dadvand, Payam; Gascon Merlos, Mireia, 1984-; Bustamante Pineda, Mariona; Rivas, Ioar; Foraster Pulido, Maria, 1984-; Basagaña Flores, Xavier; Cosín Tomàs, Marta; Ferrer Vergés, Muriel; Gómez Herrera, Laura C.; Jiménez Arenas, Pol; Júlvez Calvo, Jordi; Morillas, Àlex; Nieuwenhuijsen, Mark J.; Persavento, Cecilia; Pujol, Jesús; Vrijheid, Martine; Sunyer Deu, Jordi; BiSC Group (Oxford University Press, 2024)
• Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study

  Koch, Sarah; Prado Peralta, María Gabriela; Carsin, Anne-Elie; Abellan, Alicia; Roda, Célina; Torrent, Maties; Iñiguez, Carmen; Ballester Díez, Ferran; Ferrero, Amparo; Zabaleta, Carlos; Lertxundi, Aitana; Guxens Junyent, Mònica; Vrijheid, Martine; Sunyer Deu, Jordi; Casas Sanahuja, Maribel; García Aymerich, Judith (BMJ Publishing Group, 2024)

  Objective: The existence of catch-up lung function growth and its predictors is uncertain. We aimed to identify lung function trajectories and their predictors in a population-based birth cohort. Methods: We applied ...
• The impact of thin and thick truth: the limits of truth commission design in polarized societies

  Daniels, Lesley-Ann; Zalunardo, Virginia (Taylor & Francis, 2024)

  Dealing with the legacy of the past has become a popular demand in postconflict and posttransition countries. However, the pursuit of truth can be a divisive issue that threatens rather than promotes understanding, ...
• New interventionism: the re-politicisation of electricity governance with renewable energy policies in the UK, Mexico and Morocco

  Mathieu, Emmanuelle; Valenzuela, Jose Maria (Taylor & Francis, 2024)

  While the 1990s saw the retreat of governments from economic governance to the benefit of the market and independent regulatory agencies, we now observe a comeback of governments’ interventions in the economy. This recent ...
• Trust, mistrust and distrust as blind spots of Social Licence to Operate: illustration via three forerunner countries in nuclear waste management

  Lehtonen, Markku; Kojo, Matti; Kari, Mika; Jartti, Tuija; Litmanen, Tapio (Taylor & Francis, 2022)

  The notion of social licence to operate (SLO) has become a widely applied concept for companies in mining and resource extraction industries to manage their social and community relations, in the face of local criticism ...
• Person marking in Catalan Sign Language (LSC) personal pronouns

  Veiga Busto, Raquel (Universitat Pompeu Fabra. Servicio de Publicaciones, 2020)

  This paper addresses the question of whether the person category is grammaticalized insign language personal pronouns. Building on Berenz’s (1996) Body Coordinates Model,I argue that Catalan Sign Language (LSC) encodes the ...
• Dissecting gene activation and chromatin remodeling dynamics in single human cells undergoing reprogramming

  Martínez Sarmiento, José A.; Cosma, Maria Pia; Lakadamyali, Melike (Elsevier, 2024)

  During cell fate transitions, cells remodel their transcriptome, chromatin, and epigenome; however, it has been difficult to determine the temporal dynamics and cause-effect relationship between these changes at the ...
• Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells

  Conti, Sefora; Venturini, Valeria; Cañellas Socias, Adrià; Cortina Duran, Carme; Abenza, Juan F.; Stephan-Otto Attolini, Camille; Middendorp Guerra, Emily; Xu, Catherine K.; Li, Jia Hui; Rossetti, Leone; Stassi, Giorgio; Roca-Cusachs, Pere; Diz-Muñoz, Alba; Ruprecht, Verena; Guck, Jochen; Batlle Gómez, Eduard; Labernadie, Anna; Trepat, Xavier (Nature Research, 2024)

  Colorectal cancer (CRC) tumors are composed of heterogeneous and plastic cell populations, including a pool of cancer stem cells that express LGR5. Whether these distinct cell populations display different mechanical ...
• Intron detention tightly regulates the stemness/differentiation switch in the adult neurogenic niche

  González Iglesias, Ainara; Arcas Mantas, Aida; Domingo Muelas, Ana; Mancini, Estefanía; Galcerán, Joan; Valcárcel, J. (Juan); Fariñas, Isabel; Nieto, M. Ángela (Nature Research, 2024)

  The adult mammalian brain retains some capacity to replenish neurons and glia, holding promise for brain regeneration. Thus, understanding the mechanisms controlling adult neural stem cell (NSC) differentiation is crucial. ...
• Beyond quiescent and active: Intermediate microglial transcriptomic states in a mouse model of down syndrome

  Fernández Blanco, Álvaro; Sierra, Cesar; Tejido, Clara; Dierssen, Mara (MDPI, 2024)

  Research on microglia in Down syndrome (DS) has shown that microglial activation, increased inflammatory gene expression, and oxidative stress occur at different ages in DS brains. However, most studies resulted in simplistic ...
• LATS1 controls CTCF chromatin occupancy and hormonal response of 3D-grown breast cancer cells

  Ramírez Cuéllar, Angélica Julieta; Ferrari, Roberto; Sanz, Rosario T.; Valverde Santiago, Marta; García García, Judith; Nacht, A. Silvina; Castillo, David; Le Dily, François; Neguembor, Maria Victoria; Malatesta, Marco; Bonnin, Sarah; Martí Renom, Marc A.; Beato, Miguel; Vicent, Guillermo Pablo (Nature Research, 2024)

  The cancer epigenome has been studied in cells cultured in two-dimensional (2D) monolayers, but recent studies highlight the impact of the extracellular matrix and the three-dimensional (3D) environment on multiple cellular ...
• Single cell atlas of Xenoturbella bocki highlights limited cell-type complexity

  Robertson, Helen E.; Sebé-Pedrós, Arnau; Saudemont, Baptiste; Loe-Mie, Yann; Zakrzewski, Anne-C.; Grau Bové, Xavier; Mailhe, Marie-Pierre; Schiffer, Philipp H.; Telford, Maximilian J.; Marlow, Heather (Nature Research, 2024)

  Phylogenetic analyses over the last two decades have united a few small, and previously orphan clades, the nematodermatids, acoels and xenoturbelids, into the phylum Xenacoelomorpha. Some phylogenetic analyses support a ...

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