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Visualitza Documents OpenAIRE (Open Access Infrastructure for Research in Europe) per autoria "Isalan, Mark"

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A genetic toolkit and gene switches to limit Mycoplasma growth for biosafety applications

Broto, Alicia; Gaspari, Erika; Miravet Verde, Samuel, 1992-; Martins dos Santos, Vitor; Isalan, Mark (Nature Research, 2022)

Mycoplasmas have exceptionally streamlined genomes and are strongly adapted to their many hosts, which provide them with essential nutrients. Owing to their relative genomic simplicity, Mycoplasmas have been used to develop ...
Cooperativity to increase Turing pattern space for synthetic biology

Diambra, Luis; Senthivel, Vivek Raj, 1983-; Bárcena Menéndez, Diego, 1984-; Isalan, Mark (American Chemical Society (ACS), 2015)

It is hard to bridge the gap between mathematical formulations and biological implementations of Turing patterns, yet this is necessary for both understanding and engineering these networks with synthetic biology approaches. ...
Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution

Schaerli, Yolanda; Jiménez, Alba; Duarte, José M.; Mihajlovic, Ljiljana; Renggli, Julien; Isalan, Mark; Sharpe, James; Wagner, Andreas (Wiley-Blackwell, 2018)

Phenotypic variation is the raw material of adaptive Darwinian evolution. The phenotypic variation found in organismal development is biased towards certain phenotypes, but the molecular mechanisms behind such biases are ...
The propagation of perturbations in rewired bacterial gene networks.

Baumstark, Rebecca; Hänzelmann, Sonja, 1981-; Tsuru, Saburo; Schaerli, Yolanda; Francesconi, Mirko; Mancuso, Francesco M.; Castelo Valdueza, Robert; Isalan, Mark (Nature Publishing Group, 2015)

What happens to gene expression when you add new links to a gene regulatory network? To answer this question, we profile 85 network rewirings in E. coli. Here we report that concerted patterns of differential expression ...
β-catenin fluctuates in mouse ESCs and is essential for Nanog-mediated/nreprogramming of somatic cells to pluripotency

Marucci, Lucia; Pedone, Elisa, 1985-; Vicino, Umberto di; Sanuy-Escribano, Blanca; Isalan, Mark; Cosma, Maria Pia, 1970- (Elsevier, 2014)

The Wnt/β-catenin pathway and Nanog are key regulators of embryonic stem cell (ESC) pluripotency and the reprogramming of somatic cells. Here, we demonstrate that the repression of Dkk1 by Nanog, which leads indirectly to ...